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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cryptococcal antigenemia in anti-retroviral naïve aids patients: Prevalence and its association with CD4 cell count
Acta Medica Iranica, Volume 50, No. 5, Year 2012
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Description
Cryptococcus neoformans is the most incriminated fungal pathogen causing meningitis in acquired immune deficiency syndrome (AIDS) patients, and is known to constitute a major cause of deaths in AIDS patients. This study aimed to determine the sero-prevalence and effect of CD4 count on seropositivity for Cryptococcus neoformans antigen (crag) in antiretroviral- naïve (ART-naïve) AIDS patients. This study included 150 (61 males and 89 females) ART-naïve AIDS patients attending the Human Immunodeficiency Virus (HIV) clinic of the University of Benin teaching hospital, Benin City, Nigeria within the period February 2011- July 2011. 40 (18 males and 22 females) HIV positive outpatients with CD4 counts >200 cells/μl who are ART-naive were recruited and used as controls. The prevalence of crag in the patients and control group was determined using the cryptococcal antigen latex agglutination system (CALAS) (Meridian Bioscience, Europe) and CD4 counts were measured using flow cytometry (Partec flow cytometer, Germany). Of 150 ART-naïve AIDS patients with CD4 counts ≤ 200 cells/μL, 19 (12.7%) were positive for serum Cryptococcal antigen. ART-naïve AIDS patients with CD4 count ≤50 cells/μl had the highest prevalence of serum crag. Lower CD4 counts were significantly associated with positivity for serum crag (P<0.001). Age and Sex had no significant effect on the sero-positivity for serum crag. 1 (2.5%) of the control was sero-positive for crag. Serum crag was significantly associated with AIDS but not with HIV (P<0.001). This study uncovers a high prevalence of crag in ART-naïve AIDS patients in Benin City. There is an urgent need to introduce early and routine screening for crag in ART-naïve AIDS patients for prompt intervention. © 2012 Tehran University of Medical Sciences. All rights reserved.
Authors & Co-Authors
Osazuwa, Oghomwen Favour
Nigeria, Benin
University of Benin
Nigeria, Abuja
Wuse District General Hospital
Dirisu, Osilume
Nigeria, Benin
University of Benin
Nigeria, Benin
Lahor Research Laboratories and Medical Centre
Okuonghae, Evbaguehita
Nigeria, Benin
University of Benin
Statistics
Citations: 3
Authors: 3
Affiliations: 3
Identifiers
ISSN:
00446025
e-ISSN:
17359694
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Benin
Nigeria
Participants Gender
Female