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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fine Particulate Matter and Parkinson Disease Risk among Medicare Beneficiaries
Neurology, Volume 101, No. 21, Year 2023
Notification
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Description
Background and ObjectivesNumerous studies suggest that environmental exposures play a critical role in Parkinson disease (PD) pathogenesis, and large, population-based studies have the potential to advance substantially the identification of novel PD risk factors. We sought to study the nationwide geographic relationship between PD and air pollution, specifically PM2.5 (particulate matter with a diameter <2.5 micrometers), using population-based US Medicare data.MethodsWe conducted a population-based geographic study of Medicare beneficiaries aged 66-90 years geocoded to US counties and zip+4. We used integrated nested Laplace approximation to create age, sex, race, smoking, and health care utilization-Adjusted relative risk (RR) at the county level for geographic analyses with PM2.5 as the primary exposure of interest. We also performed an individual-level analysis using logistic regression with cases and controls with zip+4 centroid PM2.5. We adjusted a priori for the same covariates and verified no confounding by indicators of socioeconomic status or neurologist density.ResultsAmong 21,639,190 Medicare beneficiaries, 89,390 had incident PD in 2009. There was a nationwide association between average annual PM2.5 and PD risk whereby the RR of PD was 56% (95% CI 47%-66%) greater for those exposed to the median level of PM2.5 compared with those with the lowest level of PM2.5. This association was linear up to 13 g/m3 corresponding to a 4.2% (95% CI 3.7%-4.8%) greater risk of PD for each additional g/m3 of PM2.5 (ptrend < 0.0001). We identified a region with high PD risk in the Mississippi-Ohio River Valley, where the risk of PD was 19% greater compared with the rest of the nation. The strongest association between PM2.5 and PD was found in a region with low PD risk in the Rocky Mountains. PM2.5 was also associated with PD in the Mississippi-Ohio River Valley where the association was relatively weaker, due to a possible ceiling effect at average annual PM2.5 levels of ∼13 g/m3.DiscussionState-of-The-Art geographic analytic techniques revealed an association between PM2.5 and PD that varied in strength by region. A deeper investigation into the specific subfractions of PM2.5 may provide additional insight into regional variability in the PM2.5-PD association. © American Academy of Neurology.
Authors & Co-Authors
Krzyzanowski, Brittany
United States, Phoenix
Barrow Neurological Institute
Searles Nielsen, Susan
United States, St. Louis
Washington University in St. Louis
Turner, Jay R.
United States, St. Louis
Washington University in St. Louis
Racette, Brad A.
United States, Phoenix
Barrow Neurological Institute
Statistics
Citations: 1
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1212/WNL.0000000000207871
ISSN:
00283878
Research Areas
Environmental
Study Design
Cross Sectional Study