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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genome variants of human adenovirus 40 (subgroup F)
Journal of Medical Virology, Volume 14, No. 3, Year 1984
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Description
Twenty‐six strains of faecal adenovirus from three continents (two from Europe, 16 from South Africa, and eight from Canada) were typed as Ad40 by restriction enzyme analysis of the DNA using Sma I. The DNA of the strains was further compared by digestion with six other enzymes, namely Bam HI, Eco RI, Bgl I, Xho I, Sst I, and Hind III. At least two different restriction profiles were found to exist for each enzyme. Nineteen of the 26 strains studied had the same combination of profiles for all the enzymes, within the limits of resolution of the technique. This genome type was detected from all three continents and included the Finnish reference strain Hovi‐X. The other seven strains were genome variants, representing five other genome types. Three genome types were detected only in South African specimens, whereas one genome type was detected in single specimens from both South Africa and Canada. Strain Dugan from Holland, indistinguishable from other Ad40 strains in neutralization tests using polyclonal antibody preparations [de Jong et al, 1983], deviated from the common Hovi‐X‐like genome on digestion of the DNA with any of the enzymes except Sma I. Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Kidd, Alistair H.
South Africa, Johannesburg
National Institute for Communicable Diseases
Berkowitz, Frank E.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Blaskovič, P. J.
Canada, Toronto
Ministère de la Santé Ministère Des Soins de Longue Durée
Schoub, Barry David
South Africa, Johannesburg
National Institute for Communicable Diseases
Statistics
Citations: 39
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.1890140307
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Study Locations
South Africa