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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated plasmodium falciparum malaria in children from gabon
Journal of Infectious Diseases, Volume 169, No. 2, Year 1994
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Description
Multidrug resistance of Plasmodium falciparum is becoming common in Africa. In a randomized trial, four short-term regimens were compared for treating uncomplicated P. falciparum malaria in children 4–15 years old in Gabon. One hundred thirty patients received chloroquine (25 mg/kg over 48 h; group C), chloroquine (as above) plus c1indamycin (5 mg/kg every 12 h for 6 doses; group CCI), quinine (12 mg/kg every 12 h for 6 doses; group Q), or quinine (as above) plus c1indamycin (as above; group QCI). In group C, only 9% of patients were cured by day 28, 44% showed recrudescent malaria (RI), and 47% showed intermediate or high-grade resistance (RII/RIII). In group CCI, 70% of patients were cured and 30% showed recrudescences. In group Q, 32% were cured and 68% showed recrudescences. In group QCI, 88% were cured and 12% showed recrudescences after day 14. All treatment regimens were well tolerated. Thus, the combination of c1indamycin with chloroquine or quinine enhances parasite clearance and improves response to therapy. © 1994 by The University of Chicago.
Authors & Co-Authors
Kremsner, Peter G.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Berlin
Landesinstitut Für Tropenmedizin
Austria, Vienna
Universität Wien
Winkler, Stefan
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Berlin
Landesinstitut Für Tropenmedizin
Austria, Vienna
Universität Wien
Brandts, Christian H.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Berlin
Landesinstitut Für Tropenmedizin
Austria, Vienna
Universität Wien
Neifer, Stefan
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Berlin
Landesinstitut Für Tropenmedizin
Austria, Vienna
Universität Wien
Bienzel, Ulrich
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Berlin
Landesinstitut Für Tropenmedizin
Austria, Vienna
Universität Wien
Graninger, Wolfgang
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Berlin
Landesinstitut Für Tropenmedizin
Austria, Vienna
Universität Wien
Statistics
Citations: 123
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/169.2.467
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Gabon