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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Survival in dialysis patients is different between patients with diabetes as primary renal disease and patients with diabetes as a co-morbid condition
Diabetologia, Volume 56, No. 9, Year 2013
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Description
Aims/hypothesis: A previous study in Dutch dialysis patients showed no survival difference between patients with diabetes as primary renal disease and those with diabetes as a co-morbid condition. As this was not in line with our hypothesis, we aimed to verify these results in a larger international cohort of dialysis patients. Methods: For the present prospective study, we used data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry. Incident dialysis patients with data on co-morbidities (n = 15,419) were monitored until kidney transplantation, death or end of the study period (5 years). Cox regression was performed to compare survival for patients with diabetes as primary renal disease, patients with diabetes as a co-morbid condition and non-diabetic patients. Results: Of the study population, 3,624 patients (24%) had diabetes as primary renal disease and 1,193 (11%) had diabetes as a co-morbid condition whereas the majority had no diabetes (n = 10,602). During follow-up, 7,584 (49%) patients died. In both groups of diabetic patients mortality was higher compared with the non-diabetic patients. Mortality was higher in patients with diabetes as primary renal disease than in patients with diabetes as a co-morbid condition, adjusted for age, sex, country and malignancy (HR 1.20, 95% CI 1.10, 1.30). An analysis stratified by dialysis modality yielded similar results. Conclusions/interpretation: Overall mortality was significantly higher in patients with diabetes as primary renal disease compared with those with diabetes as a co-morbid condition. This suggests that survival in diabetic dialysis patients is affected by the extent to which diabetes has induced organ damage. © 2013 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Schroijen, Marielle A.
Netherlands, Leiden
Leids Universitair Medisch Centrum
van de Luijtgaarden, Moniek W.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Noordzij, Marlies
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Ravani, Pietro
Canada, Calgary
University of Calgary
Jarraya, FaïÇal
Tunisia, Sfax
Chu Hedi-chaker
Collart, Frédéric E.
Belgium, Brussels
French-belgian Esrd Registry
Prütz, Karl Göran
Sweden, Jonkoping
Swedish Renal Registry
Fogarty, Damian G.
United Kingdom, Belfast
Belfast City Hospital
Leivestad, Torbjörn O.Rn
Norway, Oslo
Oslo Universitetssykehus
Prischl, Friedrich C.
Austria, Wels
Klinikum Wels - Grieskirchen Gmbh
Wanner, Christoph
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Dekker, Friedo W.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Jager, Kitty J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Dekkers, Olaf Matthijs
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 40
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1007/s00125-013-2966-1
ISSN:
0012186X
e-ISSN:
14320428
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study