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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum
Cell, Volume 185, No. 14, Year 2022
Notification
URL copied to clipboard!
Description
The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa's Gauteng region uncovered two new sublineages, BA.4 and BA.5, which are taking over locally, driving a new wave. BA.4 and BA.5 contain identical spike sequences, and although closely related to BA.2, they contain further mutations in the receptor-binding domain of their spikes. Here, we study the neutralization of BA.4/5 using a range of vaccine and naturally immune serum and panels of monoclonal antibodies. BA.4/5 shows reduced neutralization by the serum from individuals vaccinated with triple doses of AstraZeneca or Pfizer vaccine compared with BA.1 and BA.2. Furthermore, using the serum from BA.1 vaccine breakthrough infections, there are, likewise, significant reductions in the neutralization of BA.4/5, raising the possibility of repeat Omicron infections. © 2022 The Author(s)
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9181312/bin/mmc2.mp4
https://efashare.b-cdn.net/share/pmc/articles/PMC9181312/bin/mmc1.pdf
Authors & Co-Authors
Tuekprakhon, Aekkachai
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Nutalai, Rungtiwa
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zhou, Daming
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Ginn, Helen Mary
United Kingdom, Didcot
Diamond Light Source
Liu, Chang
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mentzer, Alexander J.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Supasa, Piyada
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Duyvesteyn, Helen M.E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Skelly, Dónal Thomas
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Ritter, Thomas G.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Amini, Ali
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Bibi, Sagida
United Kingdom, Oxford
University of Oxford
Adele, Sandra
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Johnson, Síle Ann
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Constantinides, Bede
United Kingdom, Oxford
University of Oxford
Webster, Hermione J.
United Kingdom, Oxford
University of Oxford
Temperton, Nigel James
United Kingdom, Canterbury
University of Kent
Klenerman, Paul
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Barnes, Eleanor J.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dunachie, Susanna J.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
Crook, Derrick W.M.
United Kingdom, Oxford
University of Oxford
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Lambe, Teresa
United Kingdom, Oxford
University of Oxford
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Paterson, Neil G.
United Kingdom, Didcot
Diamond Light Source
Williams, Mark A.
United Kingdom, Didcot
Diamond Light Source
Hall, David Richard
United Kingdom, Didcot
Diamond Light Source
Conlon, Christopher P.
Unknown Affiliation
Deeks, Alexandra S.
Unknown Affiliation
Frater, John
Unknown Affiliation
Frending, Lisa
Unknown Affiliation
Gardiner, Siobhan
Unknown Affiliation
Jämsén, Anni
Unknown Affiliation
Jeffery, Katie J.M.
Unknown Affiliation
Malone, Tom
Unknown Affiliation
Phillips, Eloise
Unknown Affiliation
Rothwell, Lucy
Unknown Affiliation
Stafford, Lizzie
Unknown Affiliation
Fry, Elizabeth E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Huo, Jiangdong
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mongkolsapaya, Juthathip
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Ren, Jingshan
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Stuart, David Ian
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Didcot
Diamond Light Source
Screaton, Gavin Robert
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 379
Authors: 44
Affiliations: 8
Identifiers
Doi:
10.1016/j.cell.2022.06.005
ISSN:
00928674
Study Locations
South Africa