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Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19

Journal of Infectious Diseases, Volume 204, No. 1, Year 2011

Human challenges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CS17 and CS19. LSN03-016011/A (LT, CS17) elicited a dose-dependent effect, with the upper dose (6 × 109 organisms) causing diarrhea in 88% of recipients. WS0115A (LTSTp, CS19) also showed a dose response, with a 44% diarrhea rate at 9 × 109 organisms. Both strains elicited homologous antifimbrial and anti-LT antibody seroconversion. These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LT|CS17-ETEC challenge model for interventional trials.

McKenzie, Robin
1. United States, Baltimore Johns Hopkins Bayview Medical Center
2. United States, Baltimore Johns Hopkins University
Porter, Chad K.
1. United States, Silver Spring Naval Medical Research Center
Cantrell, Joyce A.
1. United States, Silver Spring Naval Medical Research Center
2. United States, Arlington United States Department of Defense
DeNearing, Barbara J.
1. United States, Baltimore Johns Hopkins University
O'Dowd, Aisling M.
1. United States, Silver Spring Naval Medical Research Center
Grahek, Shannon Lee
1. United States, Baltimore Johns Hopkins University
2. South Korea, Seoul International Vaccine Institute, Seoul
Sincock, Stephanie A.
1. United States, Silver Spring Naval Medical Research Center
2. United States, Bethesda Walter Reed National Military Medical Center
Woods, Colleen M.
1. United States, Silver Spring Naval Medical Research Center
2. United States, Bethesda C. W.
Sebeny, Peter J.
1. United States, Bethesda Uniformed Services University of the Health Sciences
2. Egypt, Cairo U.s. Naval Medical Research Unit No. 3, Egypt
Sack, David Allen
1. United States, Baltimore Johns Hopkins University
Tribble, David R.
1. United States, Bethesda Uniformed Services University of the Health Sciences
Bourgeois, August Louis
1. United States, Baltimore Johns Hopkins University
2. United States, Washington B. A. I.
Savarino, Stephen J.
1. United States, Silver Spring Naval Medical Research Center
2. United States, Bethesda Uniformed Services University of the Health Sciences

AFRICAN RESEARCH NEXUS

Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19

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AFRICAN RESEARCH NEXUS

Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19

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African Research Nexus

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