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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Synthesis of 1H-Pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line
Archiv der Pharmazie, Volume 344, No. 3, Year 2011
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Description
Synthesis of a new series of 1H-pyrazole-1-carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N-methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
El-Gamal, Mohammed I.
South Korea, Seoul
Korea Institute of Science and Technology
South Korea, Daejeon
University of Science and Technology Ust
Sim, Taebo
South Korea, Seoul
Korea Institute of Science and Technology
Hong, Jun-hee
South Korea, Gwangju
Chosun University
Yoo, Kyung-ho
South Korea, Seoul
Korea Institute of Science and Technology
Oh, Chang-hyun
South Korea, Seoul
Korea Institute of Science and Technology
South Korea, Daejeon
University of Science and Technology Ust
Statistics
Citations: 16
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/ardp.201000057
ISSN:
15214184