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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: When does weight gain matter?
American Journal of Clinical Nutrition, Volume 89, No. 5, Year 2009
Notification
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Description
Background: Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk. Objective: We aimed to determine how birth weight (BW) and weight gain to midchildhood relate to blood pressure (BP) in young adults. Design: We pooled data from birth cohorts in Brazil, Guatemala, India, the Philippines, and South Africa. We used conditional weight (CW), a residual of current weight regressed on prior weights, to represent deviations from expected weight gain from 0 to 12, 12 to 24, 24 to 48 mo, and 48 mo to adulthood. Adult BP and risk of prehypertension or hypertension (P/HTN) were modeled before and after adjustment for adult body mass index (BMI) and height. Interactions of CWs with small size-for-gestational age (SGA) at birth were tested. Results: Higher CWs were associated with increased BP and odds of P/HTN, with coefficients proportional to the contribution of each CW to adult BMI. Adjusted for adult height and BMI, no child CW was associated with adult BP, but 1 SD of BW was related to a 0.5-mm Hg lower systolic BP and a 9% lower odds of P/HTN. BW and CW associations with systolic BP and P/HTN were not different between adults born SGA and those with normal BW, but higher CW at 48 mo was associated with higher diastolic BP in those born SGA. Conclusions: Greater weight gain at any age relates to elevated adult BP, but faster weight gains in infancy and young childhood do not pose a higher risk than do gains at other ages. © 2009 American Society for Nutrition.
Authors & Co-Authors
Adair, Linda S.
Unknown Affiliation
Martorell, Reynaldo
Unknown Affiliation
Stein, Aryeh D.
Unknown Affiliation
Hallal, Pedro Curi Curi
Unknown Affiliation
Sachdev, Harshpal Singh
Unknown Affiliation
Prabhakaran, Dorairaj
Unknown Affiliation
Wills, Andrew K.
Unknown Affiliation
Norris, Shane A.
Unknown Affiliation
Dahly, Darren L.
Unknown Affiliation
Mayol, Nanette L.
Unknown Affiliation
Victora, Cesar Gomes
Unknown Affiliation
Statistics
Citations: 176
Authors: 11
Affiliations: 10
Identifiers
Doi:
10.3945/ajcn.2008.27139
ISSN:
00029165
Research Areas
Food Security
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Study Locations
South Africa