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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Celiac disease and ischemic stroke
Revue Neurologique, Volume 165, No. 11, Year 2009
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Description
Introduction: Neurological manifestations of celiac disease are various. An association with ischemic stroke is not common and has not been well documented. We report two cases. Observations: The first patient had experienced several transient ischemic strokes in the past 2 years and then had an acute ischemic stroke involving the territory of the right posterior cerebral artery. Investigations revealed celiac disease with no other recognizable etiology. The clinical course was marked by persistent visual aftereffects, but no new vascular event. The second patient had been followed since 1998 for celiac disease confirmed by pathology and serology tests. She was on a gluten-free diet. The patient had an ischemic stroke involving the territory of the left middle cerebral artery. Apart from a positive serology for celiac disease and iron deficiency anemia, the etiological work-up was negative. Discussion: The mechanisms of vascular involvement in celiac disease are controversial. The most widely incriminated factor is autoimmune central nervous system vasculitis, in which tissue transglutaminase, the main auto-antigen contributing to maintaining the integrity of endothelium tissue, plays a major role. Other mechanisms are still debated, mainly vitamin deficiency. Conclusion: Being a potentially treatable cause of ischemic stroke, celiac disease must be considered as a potential etiology of stroke of unknown cause, particularly in young patients, and even without gastrointestinal manifestations. © 2008 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
El Moutawakil, Bouchra
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Chourkani, N.
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Sibai, Manal
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Moutaouakil, Fettouma
Morocco, Tanger
Hôpital al Kortobi
Abdoh-Rafai, Mohammed Abdoh
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Bourezgui, Meryem
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Slassi, Ilham
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Statistics
Citations: 9
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.neurol.2008.09.002
ISSN:
00353787
Research Areas
Health System And Policy
Noncommunicable Diseases