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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Renal function in children suffering from sickle cell disease: Challenge of early detection in highly resource-scarce settings
PLoS ONE, Volume 9, No. 5, Article e96561, Year 2014
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Description
Background: The prevalence of Sickle cell disease is extremely high in Democratic Republic of Congo. Despite this high prevalence of the disease, data on renal abnormalities in children are rare. Method: The study proposed to assess blood pressure, glomerular function, urea and uric acid levels in 65 steady state Congolese children with homozygous sickle cell disease and 67 normal controls. Results: In Hb-SS group, blood pressure level tended to be lower than Hb-AA groups but there was no statistically significant difference (p>0.05) between the two groups. The absolute values for GFR corrected for BSA were significantly higher in Hb-SS group compared to Hb-AA group (130.5±34.1 ml/min/1.73 m2 vs 113.7± 24.5 ml/min/1.73 m2; p = 0.004). Children with Hb-SS were more likely to hyperfiltrate (30.8% of subjects) than children with Hb-AA (6.1% of subjects). Proteinuria was found in 4 (6.2%) children with Hb-SS. Uric acid level was significantly increased in children with Hb-SS compared to corresponding values in control group (4.4±1.3 mg/dl vs 3.5±1.1 mg/dl; p <0.001). Urea level was significantly decreased compared to corresponding values in Hb-AA group (15.3±8.3 mg/dl vs 22.9±10.1 mg/dl; p<0.001). Conclusion: Hyperfiltration, low creatinine, lower urea and high uric acid are more common in children with sickle cell disease than in normal controls. © 2014 Aloni et al.
Authors & Co-Authors
Aloni, Michel Ntetani
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Ngiyulu, René Makuala
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Gini-Ehungu, Jean Lambert K.
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Nsibu, Célestin Ndosimao
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Ekila, Mathilde Bothale
Congo, Leuven
University Hospital of Kinshasa
Lepira, François Bompeka
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Nseka, Nazaire Mangani
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Statistics
Citations: 35
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0096561
e-ISSN:
19326203
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Congo