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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Risk factors for Buruli ulcer disease (Mycobacterium ulcerans infection): Results from a case-control study in Ghana
Clinical Infectious Diseases, Volume 40, No. 10, Year 2005
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Description
Background. Morbidity due to Buruli ulcer disease (BUD), a cutaneous infection caused by Mycobacterium ulcerans, has been increasingly recognized in rural West Africa. The source and mode of transmission remain unknown. Methods. To identify BUD risk factors, we conducted a case-control study in 3 BUD-endemic districts in Ghana. We enrolled case patients with clinically diagnosed BUD and obtained skin biopsy specimens. M. ulcerans infection was confirmed by at least 1 of the following diagnostic methods: histopathologic analysis, culture, polymerase chain reaction, and Ziehl-Neelsen staining of a lesion smear. We compared characteristics of case patients with confirmed BUD with those of age- and community-matched control subjects using conditional logistic regression analysis. Results. Among 121 case patients with confirmed BUD, leg lesions (49%) or arm lesions (36%) were common. Male case patients were significantly more likely than female case patients to have lesions on the trunk (25% vs. 6%; P = .009). Multivariable modeling among 116 matched case-control pairs identified wading in a river as a risk factor for BUD (odds ratio [OR], 2.69; 95% confidence interval [CI], 1.27-5.68; P = .0096). Wearing a shirt while farming (OR, 0.27; 95% CI, 0.11-0.70; P = .0071), sharing indoor living space with livestock (OR, 0.36; 95% CI, 0.15-0.86; P = .022), and bathing with toilet soap (OR, 0.41; 95% CI, 0.19-0.90; P = .026) appeared to be protective. BUD was not significantly associated with penetrating injuries (P = .14), insect bites near water bodies (P = .84), bacille Calmette-Guérin vaccination (P = .33), or human immunodeficiency virus infection (P = .99). Conclusions. BUD is an environmentally acquired infection strongly associated with exposure to river areas. Exposed skin may facilitate transmission. Until transmission is better defined, control strategies in BUD-endemic areas could include covering exposed skin. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Raghunathan, Pratima L.
United States, Atlanta
National Center for Infectious Diseases
United States, Atlanta
Centers for Disease Control and Prevention
Whitney, Ellen A.Spotts
United States, Atlanta
National Center for Infectious Diseases
Asamoa, Kwame
Ghana, Accra
Ghana Health Service
Stienstra, Ymkje
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Taylor, Thomas H.
United States, Atlanta
National Center for Infectious Diseases
Amofah, George K.
Ghana, Accra
Ghana Health Service
Ofori‐Adjei, David
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Dobos, Karen M.
United States, Atlanta
Emory University School of Medicine
Guarner, Jeannette
United States, Atlanta
National Center for Infectious Diseases
Martin, Stacey
United States, Atlanta
Emory University School of Medicine
Pathak, Sonal
United States, Atlanta
National Center for Infectious Diseases
Klutse, Erasmus Y.
Ghana, Accra
Ghana Health Service
Etuaful, Samuel N.
Ghana, Accra
Ghana Health Service
van der Graaf, Winette T.A.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Van Derwerf, Tjip S.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
King, C. Harold
United States, Atlanta
Emory University School of Medicine
Tappero, Jordan W.
United States, Atlanta
National Center for Infectious Diseases
Ashford, David A.
United States, Atlanta
National Center for Infectious Diseases
Statistics
Citations: 168
Authors: 18
Affiliations: 6
Identifiers
Doi:
10.1086/429623
ISSN:
10584838
Research Areas
Environmental
Violence And Injury
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
Multi-countries
Ghana
Participants Gender
Male
Female