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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High-risk HPV types in Tunisia. A pilot study reveals an unexpectedly high prevalence of types 58 and 82 and lack of HPV 18 among female prostitutes
Journal of Medical Virology, Volume 78, No. 7, Year 2006
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Description
"High-risk" HPVs (HR-HPV) have sharply different prevalences and there is evidence to suggest this may vary according to regions. Accurate description of HR-HPV circulation is a key feature for the rational design of prevention and screening campaigns. To gain insight into HR-HPV circulation in Tunisia, a pilot study was carried out on 64 healthy prostitutes working in the Tunis area. HPV detection and typing were carried out by MY09/MY11 PCR and restriction fragment length polymorphism (RFLP). A selected set of samples was also assayed by Gp5+/Gp6+ PCR and typed by direct sequencing. Out of 64 women, 28 were HPV positive. HPV-16 and HPV-58, both members of the genus Alpha-Papillomavirus, species 9, accounted for 10 and 7 cases with a prevalence rate of 38% and 27%, respectively. HPV-82, a member of species 5, ranked third with four cases (∼15%). Types 31, 33, 35; all members of species 9 were each detected once (∼4%) while neither HPV-18 nor related members of species 7 were detected. Type 72 and 83, both members of species 3, were the only low-risk types, each detected only once (4% each). Two samples could not be typed. The prevalence of HPV types appeared sharply different from that of neighboring areas. Should the existence of epidemiological pockets be confirmed by larger, more detailed studies, screening and vaccine campaigns will have to be designed carefully taking into account the actual epidemiological context of the target population. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
De Marco, Federico
Italy, Rome
Irccs Regina Elena National Cancer Institute
Houissa-Kchouk, Fatma
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Habib Thameur
Khelifa, Ridha
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Habib Thameur
Marcante, Maria Luisa
Italy, Rome
Irccs Regina Elena National Cancer Institute
Statistics
Citations: 27
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/jmv.20646
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Cancer
Study Design
Cross Sectional Study
Study Locations
Tunisia
Participants Gender
Female