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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
A novel P106L mutation in EPSPS and an unknown mechanism(s) act additively to confer resistance to glyphosate in a South African lolium rigidum population
Journal of Agricultural and Food Chemistry, Volume 59, No. 7, Year 2011
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Description
Glyphosate resistance evolution in weeds is a growing problem in world agriculture. Here, we have investigated the mechanism(s) of glyphosate resistance in a Lolium rigidum population (DAG1) from South Africa. Nucleotide sequencing revealed the existence of at least three EPSPS homologues in the L. rigidum genome and identified a novel proline 106 to leucine substitution (P106L) in 52% DAG1 individuals. This mutation conferred a 1.7-fold resistance increase to glyphosate at the whole plant level. Additionally, a 3.1-fold resistance increase, not linked to metabolism or translocation, was estimated between wild-type P106-DAG1 and P106-STDS sensitive plants. Point accepted mutation analysis suggested that other amino acid substitutions at EPSPS position 106 are likely to be found in nature besides the P106/S/A/T/L point mutations reported to date. This study highlights the importance of minor mechanisms acting additively to confer significant levels of resistance to commercial field rates of glyphosate in weed populations subjected to high selection pressure. © 2011 American Chemical Society.
Authors & Co-Authors
Kaundun, Shiv S.
United Kingdom, Fulbourn
Syngenta uk Limited
Dale, Richard P.
United Kingdom, Fulbourn
Syngenta uk Limited
Zelaya, Ian A.
United Kingdom, Fulbourn
Syngenta uk Limited
Dinelli, Giovanni
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Marotti, Ilaria
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
McIndoe, Eddie
United Kingdom, Fulbourn
Syngenta uk Limited
Cairns, Andrew L.P.
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 89
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1021/jf104934j
ISSN:
00218561
e-ISSN:
15205118
Research Areas
Cancer
Study Design
Cross Sectional Study
Study Locations
South Africa