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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Population pharmacokinetic analysis of the active product of dipyrone
International Journal of Clinical Pharmacology and Therapeutics, Volume 48, No. 12, Year 2010
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Description
Objective: Pharmacokinetics of 4-methyl-amino-antipyrine (MAA), the active metabolite of the nonsteroidal anti-inflammatory agent dipyrone, whose time course correlates to the therapeutic effect of the drug, are studied. Study design and setting: 153 patients hospitalized in the Department of Medicine at the Hadassah University Hospital, Jerusalem, Israel. Intervention: Patients receiving dipyrone for the treatment of fever or pain were asked to participate in the study. Pharmacokinetics and statistical analysis: Using the population approach based on a formerly developed experimental model, the relationships between pharmacokinetic parameters and demographic and physiological covariates are explored. Results: The results of the analysis show considerable variability in pharmacokinetics across the study population, and a significant decrease in clearance with age. Conclusion:Apopulation pharmacokinetic analysis of MAA, the active product of dipyrone, reveals that age is a significant predictor of MAA disposition. Covariates that measure hepatic and renal function do not appear to be good predictors of the rate of MAA disposition. ©2010 Dustri-Verlag Dr. K. Feistle.
Authors & Co-Authors
Levy, M.
Israel, Jerusalem
Hadassah University Medical Centre
Muszkat, M.
Israel, Jerusalem
Hadassah University Medical Centre
Rich, B.
Canada, Montreal
Université Mcgill
Rosenkranz, Bernd
South Africa, Stellenbosch
Stellenbosch University
Schlattmann, Peter
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Statistics
Citations: 6
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.5414/CPP48791
ISSN:
09461965
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cross Sectional Study
Study Approach
Quantitative