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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and homocysteine are risk factors for coronary artery disease in Moroccan population
Journal of Biomedicine and Biotechnology, Volume 2007, Article 80687, Year 2007
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Description
Increased plasma total homocysteine (tHcy) levels have been shown to be a risk factor for coronary artery disease (CAD). The common methylenetetrahydrofolate reductase C677T (MTHFR C677T) polymorphism has been reported to be a strong predictor of mild hyperhomocysteinaemia (HHcy). We assessed whether this mutation was associated with increased risk of CAD and plasma levels of tHcy. We also evaluated interactions between this polymorphism, mild elevated tHcy levels and conventional risk factors of CAD. Method. Using PCR-RFLP analysis, we studied the frequency of the C677T genotypes and its effect on CAD and on tHcy concentrations in 400 subjects without and with CAD angiographically confirmed. There were 210 subjects with CAD and 190 subjects without CAD. Results. The frequencies of the C677T genotypes were 53% (59.5% in controls versus 48.1% in cases), 34.8% (32.1 in controls versus 37.1 in cases), and 11.8% (8.4% in controls versus 14.8% in cases), respectively, for 677CC, 677CT, and 677TT. The genotype frequencies were significantly different between case and control groups ( P<.05). The 677T allele enhances the risk of CAD associated to HHcy ( P<.01). In multivariate analysis models, MTHFR C677T polymorphism effect on CAD was masked by other risk factors. HHcy was only and independently influenced by MTHFR polymorphism and smoking habits, and it is a strong predictor of CAD independently of conventional risk factors. Conclusion. Our data suggest that HHcy is strongly and independently associated to CAD risk increase; and MTHFR C677T polymorphism and smoking habits were the main predictors of tHcy levels. The CAD risk increase is mainly associated with mild HHcy in 677TT, whereas in 677CT and 677CC it is mainly associated with the conventional risk factors. Copyright © 2007 Nawal Bennouar et al.
Authors & Co-Authors
Bennouar, N.
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Morocco, Casablanca
Hassan Ii University of Casablanca
Allami, Abdellatif
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Morocco, Tetouan
Université Abdelmalek Essaadi
Azeddoug, Houssine
Morocco, Casablanca
Hassan Ii University of Casablanca
Bendris, Abdenbi
Morocco, Tetouan
Université Abdelmalek Essaadi
Laraqui, Abdelilah
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
El Jaffali, Amal
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
El Kadiri, Nizar
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Benzidia, Rachid
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Benomar, Anwar
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Fellat, Seddik
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Benomar, Mohammed H.
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Statistics
Citations: 28
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1155/2007/80687
ISSN:
11107243
e-ISSN:
11107251
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study