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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evaluation of the efficacy of a low-passage bovine rotavirus (strain WC3) vaccine in children in Central Africa
Research in Virology, Volume 142, No. 5, Year 1991
Notification
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Description
The safety and efficacy of a WC3 rotavirus vaccine was evaluated in a double-blind placebo-controlled trial involving 472 children in Bangui (Central African Republic). Each child received two doses of either placebo (235 children) or vaccine (237 children) at a 1-month interval, the first dose being given at 3 months of age. During the follow-up survey 9 months after the first dose, 117 rotavirus diarrhoeas were observed, 59 in the placebo group, 58 in the vaccinated group. The only positive effect of the vaccine was a significantly higher proportion of mild rotavirus diarrhoeal episodes in the vaccinated group than in the placebo group. Of the children in the vaccinated group, 60% had a positive immune response to WC3 rotavirus when tested by plaque reduction seroneutralization. © 1991.
Authors & Co-Authors
Georges-Courbot, Marie Claude
France, Paris
Institut Pasteur, Paris
Monges, J.
France, Paris
Institut Pasteur, Paris
Siopathis, M. R.
Unknown Affiliation
Roungou, Jean Baptiste
Unknown Affiliation
Grésenguet, Gérard
France, Paris
Institut Pasteur, Paris
Bouquety, J. C.
Unknown Affiliation
Lanckriet, C.
Unknown Affiliation
Cadoz, Michel
France, Lyon
Institut Mérieux
Georges, Alain Jean
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 106
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/0923-2516(91)90008-Q
ISSN:
09232516
Research Areas
Disability
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Central African Republic