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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development
American Journal of Physiology - Endocrinology and Metabolism, Volume 295, No. 5, Year 2008
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Description
Low birth weight resulting from intrauterine growth retardation (IUGR) is a risk factor for further development of metabolic diseases. The pig appears to reproduce nearly all of the phenotypic pathological consequences of human IUGR and is likely to be more relevant than rodents in studies of neonatal development. In the present work, we characterized the model of low-birth-weight piglets with particular attention to the hypothalamic leptin-sensitive system, and we tested whether postnatal leptin supplementation can reverse the precocious signs of adverse metabolic programming. Our results demonstrated that 1) IUGR piglets present altered postnatal growth and increased adiposity; 2) IUGR piglets exhibit abnormal hypothalamic distribution of leptin receptors that may be linked to further disturbance in food-intake behavior; and 3) postnatal leptin administration can partially reverse the IUGR phenotype by correcting growth rate, body composition, and development of several organs involved in metabolic regulation. We conclude that IUGR may be characterized by altered leptin receptor distribution within the hypothalamic structures involved in metabolic regulation and that leptin supplementation can partially reverse the IUGR phenotype. These results open interesting therapeutic perspectives in physiopathology for the correction of defects observed in IUGR. Copyright © 2008 the American Physiological Society.
Authors & Co-Authors
Attig, Linda
France, Gif-sur-yvette
Université Paris-saclay
France, Beauvais
Institut Polytechnique Lasalle Beauvais
Djiane, Jean
France, Gif-sur-yvette
Université Paris-saclay
Gertler, Arieh
Israel, Jerusalem
Hebrew University of Jerusalem
Rampin, O.
France, Gif-sur-yvette
Université Paris-saclay
Larcher, Thibaut
France, Nantes
Oniris - Ecole Nationale Vétérinaire, Agroalimentaire et de L’alimentation
Boukthir, S.
Tunisia, Tunis
Université de Tunis el Manar, Hôpital D'enfants Béchir Hamza de Tunis
Anton, P. M.
France, Beauvais
Institut Polytechnique Lasalle Beauvais
Madec, J. Y.
France, Beauvais
Institut Polytechnique Lasalle Beauvais
Gourdou, I.
France, Gif-sur-yvette
Université Paris-saclay
Abdennebi-Najar, Latifa
France, Beauvais
Institut Polytechnique Lasalle Beauvais
Statistics
Citations: 76
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1152/ajpendo.90542.2008
ISSN:
01931849
e-ISSN:
15221555
Research Areas
Food Security
Maternal And Child Health
Noncommunicable Diseases