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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prognostic significance of macrophage invasion in hilar cholangiocarcinoma
BMC Cancer, Volume 15, No. 1, Article 790, Year 2015
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Description
Background: Tumor-associated macrophages (TAMs) promote tumor progression and have an effect on survival in human cancer. However, little is known regarding their influence on tumor progression and prognosis in human hilar cholangiocarcinoma. Methods: We analyzed surgically resected tumor specimens of hilar cholangiocarcinoma (n = 47) for distribution and localization of TAMs, as defined by expression of CD68. Abundance of TAMs was correlated with clinicopathologic characteristics, tumor recurrence and patients' survival. Statistical analysis was performed using SPSS software. Results: Patients with high density of TAMs in tumor invasive front (TIF) showed significantly higher local and overall tumor recurrence (both ρ < 0.05). Furthermore, high density of TAMs was associated with decreased overall (one-year 83.6% vs. 75.1%; three-year 61.3 % vs. 42.4%; both ρ < 0.05) and recurrence-free survival (one-year 93.9 % vs. 57.4 %; three-year 59.8% vs. 26.2%; both ρ < 0.05). TAMs in TIF and tumor recurrence, were confirmed as the only independent prognostic variables in the multivariate survival analysis (all ρ < 0.05). Conclusions: Overall survival and recurrence free survival of patients with hilar cholangiocarcinoma significantly improved in patients with low levels of TAMs in the area of TIF, when compared to those with a high density of TAMs. These observations suggest their utilization as valuable prognostic markers in routine histopathologic evaluation, and might indicate future therapeutic approaches by targeting TAMs. © 2015 Atanasov et al.
Authors & Co-Authors
Brandl, Andreas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Pratschke, Johann
Germany, Berlin
Charité – Universitätsmedizin Berlin
Statistics
Citations: 39
Authors: 3
Affiliations: 5
Identifiers
Doi:
10.1186/s12885-015-1795-7
ISSN:
14712407
Research Areas
Cancer
Study Approach
Quantitative