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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evidence for a dominant major gene conferring predisposition to hepatitis C virus infection in endemic conditions
Human Genetics, Volume 126, No. 5, Year 2009
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Description
hepatitis C virus (HCV), infecting 170 million people worldwide, is a major public health problem. In developing countries, unsafe injections and blood transfusions are thought to be the major routes of transmission. However, our previous work in a population from Egypt, endemic for HCV, revealed highly significant familial correlations, strongly suggesting the existence of both familial transmission of the virus and genetic predisposition to HCV infection. We investigated the hypothesis of genetic predisposition by carrying out a segregation analysis of HCV infection in the same population. We used a logistic regression model simultaneously taking into account a major gene effect, familial correlations and relevant risk factors. We analyzed 312 pedigrees (3,703 subjects). Overall HCV seroprevalence was 11.8% and increased with age. The main associated risk factors were previous parenteral treatment for schistosomiasis and blood transfusions. We found strong evidence for a dominant major gene conferring a predisposition to HCV infection. The frequency of the predisposing allele was 0.013, reflecting a strong predisposition to HCV infection in 2.6% of the subjects, particularly those under the age of 20. This study provides evidence for the involvement of host genetic factors in susceptibility/resistance to HCV infection in endemic conditions. © Springer-Verlag 2009.
Authors & Co-Authors
Laouenan, Cedric
France, Paris
Inserm
France, Paris
Université Paris Cité
Plancoulaine, Sabine
France, Paris
Inserm
France, Paris
Université Paris Cité
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Arafa, Naglaa A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Bakr, Iman M.A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Menia
Minia Faculty of Medicine
Rekacewicz, Claire
France, Paris
Institut Pasteur, Paris
Obach, Dorothée
France, Paris
Inserm
France, Paris
Université Paris Cité
France, Paris
Institut Pasteur, Paris
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
Abel, Laurent
France, Paris
Inserm
France, Paris
Université Paris Cité
Statistics
Citations: 10
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1007/s00439-009-0721-y
ISSN:
03406717
e-ISSN:
14321203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Egypt