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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Hepatitis B, C seroprevalence and delta viruses in HIV-1 senegalese patients at HAART initiation (retrospective study)
Journal of Medical Virology, Volume 80, No. 8, Year 2008
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Description
The aim of this study was to determine hepatitis co-infection in a cohort of HIV infected patients at their inclusion in the Senegalese Initiative of ART Access. B, C, and D Hepatitis viruses serological markers were checked retrospectively on 363 stored plasma. For HBV, the Abbott laboratories equipment IMx was used to detect HBs Ag and anti Core Ab on negative HBs Ag samples. For HDV, anti Delta Ab was performed using the Abbott Murex Kit on all HBs Ag positive samples. For HCV, anti HCV Ab was detected by IMx as double screening test and confirmed by INNO-LIA™ HCV Core of Innogenetics laboratories. The statistical analysis was done with STATA V8. The study population was composed of 164 men and 199 women aged between 16 and 66 years. The immune and virological markers averages at their enrolment were 154 cell/mm3 for TLCD4+ (n = 355 patients) and 4.9 log for viral load (n = 277 patients). HBs Ag was found in 61 patients or 16.8% and the prevalence of anti-HBc Ab was 83.2% (252/295). 2 patients or 3% on HBs Ag positive sample presents HBV/HDV co-infection Ab anti HCV was detects in 6 patients or 1.6% after confirmation and 2 patients had triple infection with HBV. These results showed that the prevalence of HBV and HCV in the population of persons living with HIV/AIDS in Senegal is similar to that found in the general population. Our data indicated that hepatitis pathology in the PLwHIV was essentially due to HBV. Further studies are needed to diagnose occult hepatitis in order to set up therapeutic strategies taking into account co-infections by hepatitis viruses in the ART programmes. © 2008 Wiley-Liss, Inc.
Authors & Co-Authors
Diop-Ndiaye, Halimatou
Senegal, Dakar
Le Dantec University Teaching Hospital
Touré-Kâne, Coumba
Senegal, Dakar
Le Dantec University Teaching Hospital
Étard, Jean François
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Lô, Gora
Senegal, Dakar
Le Dantec University Teaching Hospital
Diaw, Papa Alassane
Unknown Affiliation
Ngom-Guèye, Ndèye Fatou
Senegal, Dakar
Fann University Teaching Hospital
Guèye, Pape Mandoumbé
Senegal, Dakar
Principal Military Hospital of Dakar
Bâ-Fall, K. M.
Senegal, Dakar
Principal Military Hospital of Dakar
Ndiaye, Ibrahima Pierre
Senegal, Dakar
Fann University Teaching Hospital
Sow, Papa Salif
Senegal, Dakar
Fann University Teaching Hospital
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Mboup, Souleymane
Senegal, Dakar
Le Dantec University Teaching Hospital
Statistics
Citations: 101
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.21236
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal
Participants Gender
Male
Female