Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Epstein-barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants
PLoS ONE, Volume 5, No. 11, Article e14013, Year 2010
Notification
URL copied to clipboard!
Description
Background: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines are less effective than in high income settings. To establish whether there is an association between these two observations, we tested the hypothesis that infection with one or both viruses modulate antibody responses to the T-cell independent meningococcal polysaccharide vaccine and the T-cell dependent measles vaccines. Methodology/Principal Findings: Infection with EBV and CMV was diagnosed by the presence of virus-specific IgM in the peripheral blood or by the presence of IgG at higher levels than that found in umbilical cord blood. Anti-meningococcus IgG and IgM were quantified by ELISA. Anti-measles antibody responses were quantified by haemagglutinin antibody inhibition assay. Infants infected with EBV had reduced IgG and IgM antibody responses to meningococcal polysaccharides and to measles vaccine. Infection with CMV alone predicted no changes in the response to meningococcal polysaccharide. While CMV alone had no discernable effect on the antibody response to measles, the response of infants infected with both CMV and EBV was similar to that of infants infected with neither, suggesting that the effects of CMV infection countered the effects of EBV on measles antibody responses. Conclusions: The results of this exploratory study indicate that infection with EBV is associated with reduced antibody responses to polysaccharides and to measles vaccine, but suggest that the response to T-cell dependent antigens such as measles haemagglutinin may be restored by infection with CMV. © 2010 Holder et al.
Authors & Co-Authors
Holder, Beth
Unknown Affiliation
Miles, David J.C.
Unknown Affiliation
Kaye, Steve
Unknown Affiliation
Crozier, Sarah R.
Unknown Affiliation
Mohammed, Nuredin Ibrahim
Unknown Affiliation
Duah-Quashie, Nancy Odurowah
Unknown Affiliation
Roberts, Elishia
Unknown Affiliation
Ojuola, Olubukola O.
Unknown Affiliation
Palmero, Melba S.
Unknown Affiliation
Touray, Ebrima S.
Unknown Affiliation
Waight, Pauline A.
Unknown Affiliation
Cotten, Matt
Unknown Affiliation
Rowland-Jones, Sarah Louise
Unknown Affiliation
van der Sande, Marianne A.B.
Unknown Affiliation
Whittle, Hilton C.
Unknown Affiliation
Statistics
Citations: 36
Authors: 15
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0014013
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Exploratory Study