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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype
Genome Research, Volume 19, No. 12, Year 2009
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Description
Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a significant proportion of the reported invasive NTS in this region. Multilocus sequence analysis of invasive S. Typhimurium from Malawi and Kenya identified a dominant type, designated ST313, which currently is rarely reported outside of Africa. Whole-genome sequencing of a multiple drug resistant (MDR) ST313 NTS isolate, D23580, identified a distinct prophage repertoire and a composite genetic element encoding MDR genes located on a virulenceassociated plasmid. Further, there was evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences. Some of this genome degradation involved genes previously implicated in virulence of S. Typhimurium or genes for which the orthologs in S. Typhi are either pseudogenes or are absent. Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field. © 2009 by Cold Spring Harbor Laboratory Press.
Authors & Co-Authors
Kingsley, Robert A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Msefula, Chisomo L.
Malawi, Zomba
University of Malawi
Thomson, Nicholas Robert
United Kingdom, Hinxton
Wellcome Sanger Institute
Kariuki, Samuel M.
United Kingdom, Hinxton
Wellcome Sanger Institute
Kenya, Nairobi
Kenya Medical Research Institute
Holt, Kathryn E.
United Kingdom, Hinxton
Wellcome Sanger Institute
Gordon, Melita A.
Malawi, Zomba
University of Malawi
Harris, David E.
United Kingdom, Hinxton
Wellcome Sanger Institute
Clark, Louise N.
United Kingdom, Hinxton
Wellcome Sanger Institute
Whitehead, Sally
United Kingdom, Hinxton
Wellcome Sanger Institute
Sangal, Vartul
Germany, Berlin
Max Planck Institute for Infection Biology
Marsh, Kevin
Kenya, Nairobi
Kenya Medical Research Institute
Achtman, Mark
Germany, Berlin
Max Planck Institute for Infection Biology
Ireland, Cork
University College Cork
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
Cormican, Martin G.M.
Ireland, Galway
University of Galway
Parkhill, Julian
United Kingdom, Hinxton
Wellcome Sanger Institute
MacLennan, Calman Alexander
Malawi, Zomba
University of Malawi
United Kingdom, Birmingham
University of Birmingham
Heyderman, Robert Simon
Malawi, Zomba
University of Malawi
Dougan, Gordon J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Statistics
Citations: 512
Authors: 18
Affiliations: 7
Identifiers
Doi:
10.1101/gr.091017.109
ISSN:
10889051
e-ISSN:
15495469
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Kenya
Malawi