Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28
Beneficial Microbes, Volume 3, No. 1, Year 2012
Notification
URL copied to clipboard!
Description
The microbiota of the gastrointestinal tract (GIT) constitutes the major part of the total human microbiome and is considered to be an important regulator of human health and host metabolism. Numerous investigations in recent years have focused on the connection between the human microbiota and metabolic diseases such as obesity, type II diabetes and atherosclerosis. Yet, little is known about the impact of probiotic consumption on the GIT microbial population and the potential effect on chronic diseases. In this study, the modulation of the microbial community in the murine small intestine resulting from probiotic feeding was investigated and was found to be associated with an anti-obesity effect. Changes in the microbiota of the mouse faeces and small intestine were monitored using quantitative real-time PCR and by following the mRNA expression levels of various obesity-related biomarkers following probiotic feeding in a mouse model. Lactobacillus rhamnosus GG and Lactobacillus sakei NR28 (a putative probiotic strain isolated from kimchi) were administered at a daily level of approximately 1×108 viable bacteria per mouse (C57BL/6J mice) for up to three weeks. Feeding these strains resulted in a significant reduction of epididymal fat mass, as well as obesity-related biomarkers like acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1 in the liver. The total number and ratio of the microbial groups, i.e. Firmicutes, Bacteroidetes, Clostridium cluster I and XIVab, and Lactobacillus spp. were modulated in the small intestine, and the Firmicutes:Bacteroidetes ratio was decreased. In contrast, no noticeable effect of probiotic feeding could be detected on the faecal microbiota, neither quantitatively, nor with regard to the bacterial groups (Firmicutes, Bacteroidetes, Clostridium cluster I and XIVab, and Lactobacillus spp.) studied. © 2012 Wageningen Academic Publishers.
Authors & Co-Authors
Ji, Yosep
South Korea, Pohang
Handong Global University
Park, Hyunjoon
South Korea, Pohang
Handong Global University
Lee, Jieun
South Korea, Pohang
Handong Global University
Yeo, Soyoung
South Korea, Pohang
Handong Global University
Yang, Jaesik
South Korea, Pohang
Handong Global University
Park, Soyoung
South Korea, Pohang
Handong Global University
Cho, Gyu Sung
Germany, Karlsruhe
Max Rubner-institut, Germany
Franz, Charles M.A.P.
Germany, Karlsruhe
Max Rubner-institut, Germany
Bomba, Alojz
Slovakia, Kosice
Pavol Jozef Šafárik University in Košice
Shin, Heuynkil
South Korea, Pohang
Handong Global University
Holzapfel, Wilhelm Heinrich
South Korea, Pohang
Handong Global University
Statistics
Citations: 100
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.3920/BM2011.0046
ISSN:
18762891
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative