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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Methylene Blue halves the long-term recurrence rate in acute pilonidal sinus disease
International Journal of Colorectal Disease, Volume 23, No. 2, Year 2008
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Description
Objective: To study the potential benefits of intraoperative methylene blue (MB) use in pilonidal sinus surgery, the correlation between long-term recurrence rate and intraoperative MB use in pilonidal sinus surgery was investigated. Background: Explicit investigations of MB effects in sinus surgery are scarce and inconclusive; an effect on long-term recurrence rate has never been systematically investigated. Materials and methods: A random selection of 247 patients out of 1,960 patients with primary sinus surgery was drawn, and the patients were subjected to a telephone interview according to a specific questionnaire. The interview covered a recurrence follow-up time of 14.9 years after surgery (mean, standard deviation=3.8 years, range 8.6-25.4 years). Results: Recurrence was less likely to occur when MB was used intraoperatively (32 of 197, [16% actuarial 20-year recurrence rate, Kaplan-Meier estimate] recurrences with MB vs 15 of 50, 30% [actuarial 20-year recurrence rate, Kaplan-Meier estimate] recurrences without MB; p=0.018; log-rank test). This effect was especially pronounced in acute abscess-forming disease (8 of 46, 17% [actuarial 20-year recurrence rate, Kaplan-Meier estimate] recurrences with MB; 11 of 33, 33% [actuarial 20-year recurrence rate, Kaplan-Meier estimate] recurrences without MB; p=0.078; log-rank test) compared to chronic disease (24 of 151, 16% [actuarial 20-year recurrence rate, Kaplan-Meier estimate]) recurrences with MB; 4 of 17, 24% [actuarial 20-year recurrence rate, Kaplan-Meier estimate] recurrences without MB; p=0.35; log-rank test). Conclusions: MB application halves the long-term risk of recurrence for pilonidal sinus patients. This significant reduction in recurrence rate can be achieved by a single careful injection of non toxic inexpensive dye into the sinus at the start of the operation. MB application should therefore be considered as an integral part of pilonidal sinus surgery. © Springer-Verlag 2007.
Authors & Co-Authors
Doll, Dietrich
South Africa, Johannesburg
University of the Witwatersrand
Germany, Berlin
German Armed Forces Center for Military Mental Health
Germany, Munich
Klinikum Rechts Der Isar
Novotny, Alexander Rudolf
Germany, Munich
Klinikum Rechts Der Isar
Rothe, Ronny
Germany, Berlin
German Armed Forces Center for Military Mental Health
Kristiansen, Jette Elisabeth H.
Denmark, Sonderborg
University of Southern Denmark, Sønderborg
Wietelmann, Kai
Germany, Berlin
German Armed Forces Center for Military Mental Health
Boulesteix, Anne Laure
Germany, Munich
Tum Fakultät Für Medizin
Düsel, Wolfgang
Germany, Berlin
German Armed Forces Center for Military Mental Health
Petersen, Sven
Germany, Hamburg
Bethesda Alligemeines Krankenhaus Bergedorf
Statistics
Citations: 64
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1007/s00384-007-0393-9
ISSN:
01791958
Research Areas
Environmental
Health System And Policy
Study Design
Cohort Study