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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex
Human Molecular Genetics, Volume 21, No. 22, Article dds333, Year 2012
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Description
Primary aldosteronism (PA, autonomous aldosterone production from the adrenal cortex) causes the most common form of secondary arterial hypertension (HT), which is also the most common curable form of HT. Recent studies have highlighted an important role of mutations in genes encoding potassium channels in the pathogenesis of PA, both in human disease and in animal models. Here, we have exploited the unique features of the hyperaldosteronemic phenotype of Kcnk3 null mice, which is dependent on sexual hormones, to identify genes whose expression is modulated in the adrenal gland according to the dynamic hyperaldosteronemic phenotype of those animals. Genetic inactivation of one of the genes identified by our strategy, dickkopf-3 (Dkk3), whose expression is increased by calcium influx into adrenocortical cells, in the Kcnk3 null background results in the extension of the low-renin, potassium-rich diet insensitive hyperaldosteronemic phenotype to the male sex. Compound Kcnk3/Dkk3 animals display an increased expression of Cyp11b2, the rate-limiting enzyme for aldosterone biosyntheis in the adrenal zona glomerulosa (ZG). Our data show that Dkk3 can act as a modifier gene in a mouse model for altered potassium channel function and suggest its potential involvement in human PA syndromes. © The Author 2012. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
El Wakil, Abeer
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
France, Nice
Université Côte D'azur
Egypt, Alexandria
Faculty of Education
Bandulik, Sascha
Germany, Regensburg
Universität Regensburg
Guy, Nicolas
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
France, Nice
Université Côte D'azur
Bendahhou, Saïd
France, Nice
Université Côte D'azur
France, Nice
Laboratoire de Physiomédecine Moléculaire
France, Valbonne
Laboratoire D'excellence Canaux Ioniques D'intérêt Thérapeutique
Zennaro, Maria Christina
France, Paris
Parcc - Paris-centre de Recherche Cardiovasculaire
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Niehrs, Christof
Germany, Heidelberg
German Cancer Research Center
Armenia, Yerevan
Institute of Molecular Biology of the National Academy of Sciences of Armenia
Mari, Bernard P.
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
France, Nice
Université Côte D'azur
Warth, R.
Germany, Regensburg
Universität Regensburg
Barhanin, Jacques
France, Nice
Université Côte D'azur
France, Nice
Laboratoire de Physiomédecine Moléculaire
France, Valbonne
Laboratoire D'excellence Canaux Ioniques D'intérêt Thérapeutique
Lalli, Enzo
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
France, Nice
Université Côte D'azur
Statistics
Citations: 23
Authors: 10
Affiliations: 11
Identifiers
Doi:
10.1093/hmg/dds333
ISSN:
09646906
e-ISSN:
14602083
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Male