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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Trends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemic
PLoS ONE, Volume 9, No. 7, Article e101738, Year 2014
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Description
We aimed to study epidemic trends and predictors for transmitted drug resistance (TDR) in our region, its clinical impact and its association with transmission clusters. We included 778 patients from the AIDS Reference Center in Leuven (Belgium) diagnosed from 1998 to 2012. Resistance testing was performed using population-based sequencing and TDR was estimated using the WHO-2009 surveillance list. Phylogenetic analysis was performed using maximum likelihood and Bayesian techniques. The cohort was predominantly Belgian (58.4%), men who have sex with men (MSM) (42.8%), and chronically infected (86.5%). The overall TDR prevalence was 9.6% (95% confidence interval (CI): 7.7-11.9), 6.5% (CI: 5.0-8.5) for nucleoside reverse transcriptase inhibitors (NRTI), 2.2% (CI: 1.4-3.5) for non-NRTI (NNRTI), and 2.2% (CI: 1.4-3.5) for protease inhibitors. A significant parabolic trend of NNRTI-TDR was found (p = 0.019). Factors significantly associated with TDR in univariate analysis were male gender, Belgian origin, MSM, recent infection, transmission clusters and subtype B, while multivariate and Bayesian network analysis singled out subtype B as the most predictive factor of TDR. Subtype B was related with transmission clusters with TDR that included 42.6% of the TDR patients. Thanks to resistance testing, 83% of the patients with TDR who started therapy had undetectable viral load whereas half of the patients would likely have received a suboptimal therapy without this test. In conclusion, TDR remained stable and a NNRTI up-and-down trend was observed. While the presence of clusters with TDR is worrying, we could not identify an independent, non-sequence based predictor for TDR or transmission clusters with TDR that could help with guidelines or public health measures. © 2014 Pineda-Peña et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4086934/bin/pone.0101738.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4086934/bin/pone.0101738.s002.docx
Authors & Co-Authors
Pineda-Peña, Andrea Clemencia
Belgium, Leuven
Ku Leuven
Colombia, Bogota
Universidad Del Rosario
Ferreira, Fossie
Belgium, Leuven
Ku Leuven
Trovão, Nídia S.
Belgium, Leuven
Ku Leuven
Khouri, Ricardo
Belgium, Leuven
Ku Leuven
Derdelinckx, Inge
Belgium, Leuven
Ku Leuven
Belgium, Leuven
Ku Leuven– University Hospital Leuven
de Munter, Paul
Belgium, Leuven
Ku Leuven
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Kücherer, Claudia
Germany, Berlin
Robert Koch Institute
Kostrikis, Leontios G.
Cyprus, Nicosia
University of Cyprus
Nielsen, Claus M.
Denmark, Copenhagen
Statens Serum Institut
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Stanojevic, Maja
Serbia, Belgrade
University of Belgrade
Paredes, Roger
Unknown Affiliation
Balotta, Claudia
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Albert, Jan
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Gómez-López, Arley
Colombia, Bogota
Universidad Del Rosario
van Wijngaerden, Eric
Belgium, Leuven
Ku Leuven
Belgium, Leuven
Ku Leuven– University Hospital Leuven
van Ranst, Marc A.
Belgium, Leuven
Ku Leuven
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Vercauteren, Jurgen
Belgium, Leuven
Ku Leuven
Vandamme, Anne Mieke
Belgium, Leuven
Ku Leuven
Portugal, Lisbon
Universidade Nova de Lisboa
van Laethem, Kristel V.
Belgium, Leuven
Ku Leuven
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Statistics
Citations: 31
Authors: 21
Affiliations: 14
Identifiers
Doi:
10.1371/journal.pone.0101738
ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male