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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis
International Journal of Antimicrobial Agents, Volume 26, No. 1, Year 2005
Notification
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Description
This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400 mg every 8 h infused over 60 min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients. © 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Authors & Co-Authors
Gous, Andries G.S.
South Africa, Sovenga
University of Limpopo
Lipman, Jeffrey
Australia, Brisbane
The University of Queensland
Australia, Brisbane
Royal Brisbane and Women's Hospital
Scribante, Juan
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Tshukutsoane, Shephelia
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
HON, H.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Pinder, Mary
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Mathivha, Rudo Lufuno
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Verhoef, L.
South Africa
Bayer (pty and ag Germany)
Stass, H.
South Africa
Bayer (pty and ag Germany)
Statistics
Citations: 49
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.ijantimicag.2005.04.005
ISSN:
09248579
Research Areas
Cancer