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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Diabetes is a risk factor for pulmonary tuberculosis: A Case-Control study from Mwanza, Tanzania
PLoS ONE, Volume 6, No. 8, Article e24215, Year 2011
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Description
Background: Diabetes and TB are associated, and diabetes is increasingly common in low-income countries where tuberculosis (TB) is highly endemic. However, the role of diabetes for TB has not been assessed in populations where HIV is prevalent. Methods: A case-control study was conducted in an urban population in Tanzania among culture-confirmed pulmonary TB patients and non-TB neighbourhood controls. Participants were tested for diabetes according to WHO guidelines and serum concentrations of acute phase reactants were measured. The association between diabetes and TB, and the role of HIV as an effect modifier, were examined using logistic regression. Since blood glucose levels increase during the acute phase response, we adjusted for elevated serum acute phase reactants. Results: Among 803 cases and 350 controls the mean (SD) age was 34.8 (11.9) and 33.8 (12.0) years, and the prevalence of diabetes was 16.7% (95% CI: 14.2; 19.4) and 9.4% (6.6; 13.0), respectively. Diabetes was associated with TB (OR 2.2, 95% CI: 1.5; 3.4, p<0.001). However, the association depended on HIV status (interaction, p = 0.01) due to a stronger association among HIV uninfected (OR 4.2, 95% CI: 1.5; 11.6, p = 0.01) compared to HIV infected (OR 0.1, 95% CI: 0.01; 1.8, p = 0.13) after adjusting for age, sex, demographic factors and elevated serum acute phase reactants. Conclusion: Diabetes is a risk factor for TB in HIV uninfected, whereas the association in HIV infected patients needs further study. The increasing diabetes prevalence may be a threat to TB control. © 2011 Faurholt-Jepsen et al.
Authors & Co-Authors
Faurholt-Jepsen, Daniel
Denmark, Copenhagen
Københavns Universitet
Range, Nyagosya Segere
Tanzania, Tanga
National Institute for Medical Research Tanga
PrayGod, George
Tanzania, Tanga
National Institute for Medical Research Tanga
Jeremiah, Kidola
Tanzania, Tanga
National Institute for Medical Research Tanga
Faurholt-Jepsen, Maria
Denmark, Copenhagen
Københavns Universitet
Aabye, Martine Grosos
Denmark, Copenhagen
Københavns Universitet
Changalucha, John M.
Tanzania, Tanga
National Institute for Medical Research Tanga
Christensen, Dirk Lund
Denmark, Copenhagen
Københavns Universitet
Denmark, Herlev
Steno Diabetes Center Copenhagen
Pipper, Christian Bressen
Denmark, Copenhagen
Københavns Universitet
Krarup, Henrik B.
Denmark, Aalborg
Aalborg Universitetshospital
Witte, Daniel R.
Denmark, Herlev
Steno Diabetes Center Copenhagen
Andersen, Aase Bengaard
Denmark, Odense
Odense Universitetshospital
Friis, Henrik M.U.
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 139
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0024215
e-ISSN:
19326203
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Tanzania