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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ-2 gene on obesity risk and leptin levels in a Tunisian population
Clinical Biochemistry, Volume 42, No. 16-17, Year 2009
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Description
Objectives: This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor γ-2 (PPARγ-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population. Design and Methods: The study included 387 obese patients and 288 control subjects. The Pro12Ala genotype was determined by polymerase chain reaction followed by a digestion with the restriction of endonuclease BstUI. Results: In the whole population, there is no significant difference in genotype frequencies of the Pro12Ala polymorphism between obese patients and controls. However, separate analysis by gender revealed that obese men (but not women) had significantly higher frequency of Pro/Ala genotypes compared to controls (12.2% vs. 4.1%; χ2 = 6.76, p = 0.009). In comparison to Pro/Pro homozygotes, Ala-allele bearers had a significantly higher risk of obesity [OR (95% CI) = 3.26 (1.28-8.33)]. When obese subjects were stratified according to type 2 diabetes status, the association with obesity was only significant in obese non-diabetic patients [OR (95% CI) = 3.74 (1.43-9.74), p = 0.007]. Additionally, obese male patients carrying the Ala-allele had significantly higher body mass index (p = 0.007) and plasma leptin levels (p = 0.023) compared to those homozygous for Pro-allele. The significant effect of Pro12Ala polymorphism on plasma leptin levels disappeared after adjustment for age and BMI. Conclusion: The present study provides evidence that the Pro12Ala polymorphism of the PPARγ-2 gene is associated with obesity in non-diabetic men from Tunisian origin. © 2009.
Authors & Co-Authors
Ben Ali, Samir
Tunisia, Tunis
Hôpital la Rabta
Ben Yahia, Fatma
Tunisia, Tunis
Hôpital la Rabta
Sédiri, Yousra
Tunisia, Tunis
Hôpital la Rabta
Kallel, Amani
Tunisia, Tunis
Hôpital la Rabta
Ftouhi, Bochra
Tunisia, Tunis
Hôpital la Rabta
Feki, Moncef
Tunisia, Tunis
Hôpital la Rabta
Allal-Elasmi, Monia
Tunisia, Tunis
Hôpital la Rabta
Haj-Taïeb, Sameh
Tunisia, Tunis
Hôpital la Rabta
Souheil, Omar
Tunisia, Tunis
Hôpital la Rabta
Sanhagi, Haifa
Tunisia, Tunis
Hôpital la Rabta
Slimane, Hédia
Tunisia, Tunis
Hôpital la Rabta
Jemaa, Riadh
Tunisia, Tunis
Hôpital la Rabta
Kâabachi, Naziha
Tunisia, Tunis
Hôpital la Rabta
Statistics
Citations: 50
Authors: 13
Affiliations: 1
Identifiers
Doi:
10.1016/j.clinbiochem.2009.08.019
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male
Female