Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Loss to follow-up among infants in a study of isoniazid prophylaxis (P1041) in South Africa
International Journal of Tuberculosis and Lung Disease, Volume 17, No. 1, Year 2013
Notification
URL copied to clipboard!
Description
OBJECTIVE: To assess risk factors for loss to follow-up (LFU) from the IMPAACT P1041 study, an isoniazid (INH) prophylaxis study conducted in southern Africa. DESIGN: Infants in two cohorts, human immunodeficiency virus-infected (HIV+) and HIV-exposed but noninfected (HIV-), were randomized to INH or placebo for 96 weeks. LFU was evaluated at week 96. RESULTS: Of 1351 infants, 12.9% were LFU (10.4% HIV+, 14.7% HIV-); 65% of the HIV+ cohort was asymptomatic. Among HIV+ infants, large household size (>6 vs. <4 members, P = 0.035) and presence of an elder (≥55 years, P = 0.05) were associated with better retention. Although attenuated in adjusted analysis, these associations held among HIV- infants. Among HIV- infants, having a younger mother increased the risk (P = 0.008) and maternal history of TB reduced the risk of LFU, the latter by nearly 70% (P = 0.048 univariate, 0.09 adjusted). LFU was largely due to inability to contact the participant (58% HIV+, 30% HIV-), and inability to attend the clinic and withdrawal of consent (HIV-). CONCLUSIONS: Household support was an important factor in participant retention, particularly for the non-HIV-infected cohort, as young maternal age was a risk factor for LFU. Retaining study participants from this mobile population can be challenging and may warrant additional support. © 2013 The Union.
Authors & Co-Authors
Beneri, Christy A.
Unknown Affiliation
Zeldow, Bret
Unknown Affiliation
Nachman, Sharon A.
Unknown Affiliation
van der Linde, Mercia
Unknown Affiliation
Pillay, Enbavani
Unknown Affiliation
Dittmer, Sylvia
Unknown Affiliation
Kim, Soyeon
Unknown Affiliation
Jean-Philippe, Patrick
Unknown Affiliation
Coetzee, Joan
Unknown Affiliation
Bobat, Raziya A.
Unknown Affiliation
Hawkins, Elizabeth
Unknown Affiliation
Violari, Avy
Unknown Affiliation
Statistics
Citations: 12
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.5588/ijtld.12.0282
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
South Africa