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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Role of angiogenic factors in acute experimental Strongyloides venezuelensis infection
Parasite Immunology, Volume 32, No. 6, Year 2010
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Description
This study aims to investigate the role of angiogenic factors in the pathogenesis of experimental strongyloidiasis. Two complementary approaches were used: Firstly, CD1 mice were treated with endostatin, an angiogenesis inhibitor, and infected with Strongyloides venezuelensis. Also, the mechanisms involved in this process were studied. Parasitological examination revealed a significant decrease in egg per gram of faeces, number of collected larvae from lung tissue and number of collected adult females in mice treated with endostatin. Direct mechanisms with diminution of angiogenesis factors and an indirect mechanism with increase of eosinophil perhaps produced their effect. Secondly, the effect of the antigens responsible for stimulation of angiogenic factors [vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2)] from alveolar macrophages and the mechanisms involved in their production were investigated. Alveolar macrophage cells obtained by bronchoalveolar lavage were incubated at different concentrations of somatic and excretory/secretory antigens of S. venezuelensis. Also, mRNA levels of VEGF and FGF2 in macrophage cells were detected by RT-PCR. L3-PBS larvae antigens induced angiogenic factors. The relationship between angiogenesis factors and nitric oxide has been observed using nitric oxide synthase inhibitors. © 2010 Blackwell Publishing Ltd.
Authors & Co-Authors
Shariati, F.
Spain, Salamanca
Universidad de Salamanca
Pérez-Arellano, José Luís
Spain, Las Palmas de Gran Canaria
Facultad de Ciencias de la Salud de la Universidad de Las Palmas de Gran Canaria
López-Abán, Julio
Spain, Salamanca
Universidad de Salamanca
El Behairy, Ahmed M.
Egypt, Giza
Faculty of Veterinary Medicine
Muro, Antonio
Spain, Salamanca
Universidad de Salamanca
Statistics
Citations: 13
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-3024.2010.01202.x
ISSN:
01419838
e-ISSN:
13653024
Research Areas
Cancer
Participants Gender
Female