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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Detection of HIV type 1 gag-specific CD4
+
T cell responses in acutely infected infants
AIDS Research and Human Retroviruses, Volume 24, No. 2, Year 2008
Notification
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Description
Multiple HIV-1-specific cytokine and proliferative responses by CD4 + T cells have not been studied in acutely infected infants. Using an intracellular cytokine staining assay, 34 untreated clade C HIV-1-infected infants (2-102 days old) were assessed for IFN-γ, 28/34 for IL-2, and 26/34 for TNF-α responses to all HIV-1 proteins. Responses were detected in 29%, 36%, and 15% of infants, respectively. Twelve of the original 34 infants were then studied longitudinally for 14 months to determine the effect of viral load on IFN-γ Gag-specific responses: seven infants were treated for 1 year, stopped treatment, and resumed when CD4% was <20 and five infants were treated only when the CD4% was <20. Following treatment cessation, there was an immediate increase in viral load followed by an increase in the magnitude of CD4+ Gag-specific responses. Despite this, the majority of infants (54%) had to restart treatment by 24 months of age, indicating that the immune responses were antigen driven but not associated with protection. Among untreated infants HIV-specific CD4+ responses were detected sporadically indicating a dysfunctional immune response in the face of constant exposure to high levels of viremia. © 2008 Mary Ann Liebert, Inc.
Authors & Co-Authors
Ramduth, Danni
South Africa, Durban
The Nelson R. Mandela Medical School
Thobakgale, Christina F.
South Africa, Durban
The Nelson R. Mandela Medical School
Mkhwanazi, Nompumelelo Prudence
South Africa, Durban
The Nelson R. Mandela Medical School
de Pierres, Chantal
South Africa, Durban
The Nelson R. Mandela Medical School
Reddy, Sharon
South Africa, Durban
The Nelson R. Mandela Medical School
van der Stok, Mary
South Africa, Durban
The Nelson R. Mandela Medical School
Mncube, Zenele
South Africa, Durban
The Nelson R. Mandela Medical School
Mphatswe, Wendy P.
South Africa, Durban
The Nelson R. Mandela Medical School
Blanckenberg, Natasha
South Africa, Durban
The Nelson R. Mandela Medical School
Cengimbo, Ayanda
South Africa, Durban
The Nelson R. Mandela Medical School
Prendergast, Andrew J.
United Kingdom, Oxford
Nuffield Department of Medicine
Tudor-Williams, Gareth
United Kingdom, Oxford
Nuffield Department of Medicine
Dong, Krista L.
United States, Boston
Massachusetts General Hospital
Jeena, Prakash Mohan
South Africa, Durban
The Nelson R. Mandela Medical School
Coovadia, Hoosen Mahomed
South Africa, Durban
The Nelson R. Mandela Medical School
Day, Cheryl Cheryl L.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Boston
Massachusetts General Hospital
Kiepiela, Photini
South Africa, Durban
The Nelson R. Mandela Medical School
Goulder, Philip Jeremy Renshaw
South Africa, Durban
The Nelson R. Mandela Medical School
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Boston
Massachusetts General Hospital
Walker, Bruce D.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Boston
Massachusetts General Hospital
United States, Chevy Chase
Howard Hughes Medical Institute
Statistics
Citations: 19
Authors: 19
Affiliations: 4
Identifiers
Doi:
10.1089/aid.2007.0096
ISSN:
08892229
Research Areas
Infectious Diseases