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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A comparison of the variable antigens expressed by clone iv-1 and subgroup iii of neisseria meningitidis serogroup a
Journal of Infectious Diseases, Volume 165, No. 1, Year 1992
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Description
Serogroup A Neisseria meningitidis of subgroup III has caused two pandemics of meningococcal meningitis since 1966 and recently spread to East Africa. The last epidemics in West Africa in the early 1980s were caused by clone IV-1. Surface antigens of clone IV-1 strains from West Africa and subgroup III strains from both pandemic waves were analyzed. Lipopolysaccharide was stable within clone IV-1 but variable in subgroup III. Pili from clone IV-1 possessed class I epitopes, while those from subgroup III also possessed class IIa epitopes. Certain class 5 protein variants were expressed by both bacterial clones, possibly reflecting either inheritance of primeval genes or horizontal transmission. Exposure of Gambians to clone IV-1 bacteria stimulated production of bactericidal antibodies cross-reactive with subgroup III bacteria in some individuals but of type-specific antibodies in others. Gambians without bactericidal antibodies usually became healthy carriers rather than developing meningococcal disease on exposure to virulent meningococci. © 1992 Oxford University Press.
Authors & Co-Authors
Achtman, Mark
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Kušećek, Barica
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Morelli, Giovanna
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Eickmann, Kirsten
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Jianfu, Wang
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Crowe, Brian A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
United States, Round Lake
Baxter Healthcare Corporation
Wall, Robert A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
United Kingdom, Harrow
Northwick Park Hospital
Hassan-King, Musa K.A.
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Moore, Patrick S.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
United States, San Francisco
Ucsf Center for Aids Prevention Studies
Zollinger, Wendell D.
Germany, Berlin
Max Planck Institute for Molecular Genetics
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United States, Silver Spring
Walter Reed Army Institute of Research
Statistics
Citations: 80
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/165.1.53
ISSN:
00221899
e-ISSN:
15376613
Study Locations
Multi-countries