Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of Indapamide SR Compared With Enalapril in Elderly Hypertensive Patients With Type 2 Diabetes
American Journal of Hypertension, Volume 20, No. 1, Year 2007
Notification
URL copied to clipboard!
Description
Background: Blood pressure control is the main influential variable in reducing microalbuminuria in patients with type 2 diabetes. In this subanalysis of the Natrilix SR versus Enalapril Study in hypertensive Type 2 diabetics with micrOalbuminuRia (NESTOR) study, we have compared the effectiveness of indapamide sustained release (SR) and enalapril in reducing blood pressure and microalbuminuria in patients ≥65 years of age. Methods: Of the 570 hypertensive patients with type 2 diabetes and persistent microalbuminuria in the NESTOR study, 187 (33%) individuals ≥65 years of age were included in this analysis. Of these, 95 patients received indapamide SR 1.5 mg and 92 patients received enalapril 10 mg, taken once daily in both cases. Adjunctive amlodipine and/or atenolol was added if required. Results: The urinary albumin-to-creatinine ratio decreased by 46% in the indapamide SR group and 47% in the enalapril group. Noninferiority of indapamide SR over enalapril was demonstrated (P = .0236; 35% limit of noninferiority) with a ratio of 0.95 (95% CI: 0.68, 1.34). Mean arterial pressure decreased by 18 mm Hg and 15 mm Hg in the indapamide SR and the enalapril groups, respectively (P = .1136). The effects of both treatments seen in these elderly patients were similar to those observed in the main population, although the extent of the reduction in microalbuminuria was slightly higher. Both treatments were well tolerated, and no difference between groups was observed regarding glucose or lipid profiles. Conclusion: Indapamide SR is not less effective than enalapril in reducing microalbuminuria and blood pressure in patients aged >65 years of age with type 2 diabetes and hypertension. © 2007 American Journal of Hypertension, Ltd.
Authors & Co-Authors
García-Puig, Juan
Spain, Madrid
Hospital Universitario la Paz
Marre, Michel
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Kokot, Franciszek
Poland, Katowice
Slaski Uniwersytet Medyczny w Katowicach
Fernandez, Margarita
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Jermendy, György
Hungary, Budapest
Bajcsy-zsilinszky Kórház
Opie, LionelH H.
South Africa, Observatory
Groote Schuur Hospital
Moyseev, Valentin
Russian Federation, Moscow
Hospital 64
Scheen, André J.
France, Bagnolet
Saft
Ionescu-Tîrgovişte, Constantin
Romania, Bucharest
Nutrition and Metabolic Diseases 'n. Paulescu'
Saldanha, M. Helena
Portugal, Coimbra
Centro Hospitalar e Universitário de Coimbra
Halabe, Aaron
Israel, Holon
Edith Wolfson Medical Center Israel
Williams, Bryan Robinson
United Kingdom, Leicester
Leicester Medical School
Mion Júnior, Décio
Brazil, Sao Paulo
Universidade de São Paulo
Ruiz, Maximino
Argentina, Buenos Aires
Hospital de Clíncas
Hermansen, Kjeld
Denmark, Aarhus
Aarhus Universitetshospital
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finizola, Bartolomé
Venezuela, Barquisimeto
Asociación Cardiovascular Centroccidental, Venezuela
Gallois, Yves
France, Lille
Chu Lille
Amouyel, Philippe
France, Lille
Institut Pasteur de Lille
Ollivier, Jean Pierre
France, Paris
Hôpital Des Instructions Des Armées Val-de Grâce
Asmar, Roland G.
Unknown Affiliation
Statistics
Citations: 24
Authors: 21
Affiliations: 21
Identifiers
Doi:
10.1016/j.amjhyper.2006.05.018
ISSN:
08957061
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study