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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Eurasian and African mitochondrial DNA influences in the Saudi Arabian population
BMC Evolutionary Biology, Volume 7, Article 32, Year 2007
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Description
Background. Genetic studies of the Arabian Peninsula are scarce even though the region was the center of ancient trade routes and empires and may have been the southern corridor for the earliest human migration from Africa to Asia. A total of 120 mtDNA Saudi Arab lineages were analyzed for HVSI/II sequences and for haplogroup confirmatory coding diagnostic positions. A phylogeny of the most abundant haplogroup (preHV)1 (R0a) was constructed based on 13 whole mtDNA genomes. Results. The Saudi Arabian group showed greatest similarity to other Arabian Peninsula populations (Bedouin from the Negev desert and Yemeni) and to Levantine populations. Nearly all the main western Asia haplogroups were detected in the Saudi sample, including the rare U9 clade. Saudi Arabs had only a minority sub-Saharan Africa component (7%), similar to the specific North-African contribution (5%). In addition, a small Indian influence (3%) was also detected. Conclusion. The majority of the Saudi-Arab mitochondrial DNA lineages (85%) have a western Asia provenance. Although the still large confidence intervals, the coalescence and phylogeography of (preHV)1 haplogroup (accounting for 18% of Saudi Arabian lineages) matches a Neolithic expansion in Saudi Arabia. © 2007 Abu-Amero et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1810519/bin/1471-2148-7-32-S1.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC1810519/bin/1471-2148-7-32-S2.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC1810519/bin/1471-2148-7-32-S3.xls
Authors & Co-Authors
Abu-Amero, Khaled Khader
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Gonźlez, Ana M.
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Larruga, José María
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Bosley, Thomas M.
United States, Camden
Cooper University Hospital
Cabrera, Vicente Martínez
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Statistics
Citations: 114
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1186/1471-2148-7-32
e-ISSN:
14712148
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study