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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Racial differences in CYP1A1 genotype and function
Toxicology Letters, Volume 77, No. 1-3, Year 1995
Notification
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Description
The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism. No concordance was observed in Africans or African-Americans between any of the 3 polymorphisms, (Mspl restriction fragment length polymorphism (RFLP) - 'M', exon 7 - 'E', new RFLP - 'A') in contrast to the concordance seen between the M and E polymorphisms in Caucasians and Asians. We observed an effect of the E polymorphism on enzyme activity and mRNA induction in Asians and Caucasians. © 1995.
Authors & Co-Authors
Taioli, Emanuela
United States, New York
Nyu Grossman School of Medicine
Crofts, Frances G.
United States, New York
Nyu Grossman School of Medicine
Trachman, Julie D.
United States, New York
Nyu Grossman School of Medicine
Bayo, Siné
Mali, Bamako
National Institute of Research in Public Health
Toniolo, Paolo G.
United States, New York
Nyu Grossman School of Medicine
Garte, Seymour J.
United States, New York
Nyu Grossman School of Medicine
Statistics
Citations: 42
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/0378-4274(95)03318-1
ISSN:
03784274
Research Areas
Cancer
Genetics And Genomics
Substance Abuse