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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Trophoblast debris modulates the expression of immune proteins in macrophages: A key to maternal tolerance of the fetal allograft?
Journal of Reproductive Immunology, Volume 94, No. 2, Year 2012
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Description
Interactions between maternal immune cells and the placenta are of substantial interest since diseases of pregnancy, such as recurrent miscarriage, villitis of unknown etiology and preeclampsia may arise due to inadequate adaptation of the maternal immune system. During normal pregnancy trophoblast debris is shed from the placenta into the maternal blood in large quantities. This trophoblast debris is then rapidly cleared from the maternal circulation. In this study, we exposed trophoblast debris generated from an in vitro placental explant model to peripheral blood-derived macrophages and quantified a variety of molecules that are important in immune responses by ELISA or flow cytometry. Phagocytosis of trophoblast debris resulted in reduced cell-surface expression of MHC-II molecules, the costimulatory molecules (CD80, CD86, CD40 and B7H3), monocyte chemoattractant protein-1 (MCP-1), inter-cellular adhesion molecule 1 (ICAM-1) and IL-8 receptors in macrophages while the expression of programmed death-1 ligand 1 (PD-L1) was upregulated. In addition, phagocytosis of trophoblast debris induced the secretion of the anti-inflammatory cytokines IL-10, IL6 and IL1Ra and decreased the secretion of pro-inflammatory cytokines IL-1β, IL12p70 and IL-8 by macrophages. Phagocytosis of trophoblast debris also increased macrophage expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO). We have shown that phagocytosis of trophoblast debris from normal placentae alters the phenotype of macrophages such that they are likely to deviate maternal immune responses towards tolerance and away from inflammation. This may be one of the mechanisms that allow the human fetal allograft to survive in direct contact with the maternal immune system. © 2012 Elsevier Ireland Ltd.
Authors & Co-Authors
Abumaree, Mohamed Hassan
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Chamley, L. William C.
New Zealand, Auckland
School of Medicine
New Zealand, Auckland
Greenlane Clinical Centre
Badri, Motasim A.
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
El-Muzaini, Mohammed F.
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Statistics
Citations: 101
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.jri.2012.03.488
ISSN:
01650378
e-ISSN:
18727603
Research Areas
Maternal And Child Health
Sexual And Reproductive Health