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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Aging, Volume 12, No. 12, Year 2020
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Description
Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in C. elegans the overexpression of humanin is sufficient to increase lifespan, dependent on daf-16/Foxo. Humanin transgenic mice have many phenotypes that overlap with the worm phenotypes and, similar to exogenous humanin treatment, have increased protection against toxic insults. Treating middle-aged mice twice weekly with the potent humanin analogue HNG, humanin improves metabolic healthspan parameters and reduces inflammatory markers. In multiple species, humanin levels generally decline with age, but here we show that levels are surprisingly stable in the naked mole-rat, a model of negligible senescence. Furthermore, in children of centenarians, who are more likely to become centenarians themselves, circulating humanin levels are much greater than age-matched control subjects. Further linking humanin to healthspan, we observe that humanin levels are decreased in human diseases such as Alzheimer's disease and MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes). Together, these studies are the first to demonstrate that humanin is linked to improved healthspan and increased lifespan. © Yen et al.
Authors & Co-Authors
Mattison, Julie A.
Unknown Affiliation
Buffenstein, Rochelle B.
United States, San Antonio
University of Texas Health Science Center at San Antonio
United States, San Francisco
Calico Llc
Atzmon, Gil
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Israel, Haifa
University of Haifa
Wallace, Douglas C.
United States, Philadelphia
University of Pennsylvania
Barzilai, Nir
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 63
Authors: 5
Affiliations: 8
Identifiers
Doi:
10.18632/aging.103534
ISSN:
19454589
Research Areas
Environmental
Maternal And Child Health
Noncommunicable Diseases