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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Polymorphisms of Hepatitis C virus non-structural protein 5A and core protein and clinical outcome of pegylated-interferon/ribavirin combination therapy
Intervirology, Volume 55, No. 1, Year 2011
Notification
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Description
Objective: Hepatitis C virus (HCV genome) polymorphisms are thought to influence the outcome of pegylated-interferon/ribavirin (PEG-IFN/RBV) therapy. This study aimed to examine non-structural protein 5A (NS5A) polymorphisms, e.g. IFN/RBV resistance-determining region (IRRDR) and IFN sensitivity-determining region (ISDR), and core protein polymorphism as predictive therapeutic markers. Methods: Pretreatment sequences of NS5A and core regions were analyzed in 68 HCV-1b-infected patients treated with PEG-IFN/RBV. Results: Of 24 patients infected withHCV having an IRRDR with 6 or more mutations (IRRDR≥6), 18 (75%) patients achieved sustained virological response (SVR), whereas only 11 (25%) of 44 patients infected with HCV having IRRDR≤5 did. IRRDR≥6 was significantly associated with SVR (p < 0.0001). On the other hand, ISDR≥2 was significantly associated with relapse (either before [breakthrough] or after end-of-treatment response [ETR[-]relapse]) (p < 0.05) and a point mutation of the core protein from Arg to Gln at position 70 (Gln 70) was significantly associated with null-response (p < 0.05). Multivariate analysis identified IRRDR≥6 as the only viral genetic factor that independently predicted SVR. Conclusion: NS5A (IRRDR and ISDR) and core protein polymorphisms are associated with the outcome of PEG-IFN/RBV therapy for chronic hepatitis C. In particular, IRRDR≥6 is a useful marker for prediction of SVR. Copyright © 2011 S. Karger AG, Basel.
Authors & Co-Authors
El-Shamy, Ahmed M.
Japan, Kobe
Graduate School of Medicine
Egypt, Ismailia
Faculty of Veterinary Medicine
Kim, Sooryang
Japan, Kobe
Kobe Asahi Hospital
Ide, Yoshihiro
Japan, Kobe
Graduate School of Medicine
Sasase, Noriko
Japan, Kobe
Kobe Asahi Hospital
Imoto, Susumu
Japan, Kobe
Kobe Asahi Hospital
Deng, Lin
Japan, Kobe
Graduate School of Medicine
Shoji, Ikuo
Japan, Kobe
Graduate School of Medicine
Hotta, Haku
Japan, Kobe
Graduate School of Medicine
Statistics
Citations: 28
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1159/000322219
ISSN:
03005526
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases