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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic analysis of HAV strains in Tunisia reveals two new antigenic variants
Virus Genes, Volume 35, No. 2, Year 2007
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Description
To evaluate the genetic variability of hepatitis A virus (HAV) isolates in Tunisia, serum samples were collected from 99 patients in different Tunisian areas in 2003 containing 92 cases with acute hepatitis, five with severe acute hepatitis and two with fulminant hepatitis. The entire VP1 gene was amplified and sequenced. Sequences were then aligned and a phylogenetic analysis was performed. Additionally, the amino acid (aa) sequence of the VP1 was determined. The analysis of Tunisian HAV isolates revealed that all the isolates were sub-genotype IA with 96.4%-99.8% of identity and showed the emergence of two novel antigenic variants. The Tun31-03 antigenic variant, with a 38 aa deletion containing Met156, Val171, Leu174 and Ala176 and located between 150 and 187 aa of the VP1 protein where neutralization escape mutations, was found. The second antigenic variant, Tun36-03, was isolated from a patient with fulminant hepatitis and presented a substitution of Thr by Pro at position 10 of the VP1 protein. This amino acid is located in a peptide presenting an antigenically reactive epitope of the VP1 protein. This substitution has never been described previously. © 2007 Springer Science+Business Media, LLC.
Authors & Co-Authors
Gharbi-Khélifi, Hakima
Tunisia, Monastir
Faculté de Pharmacie de Monastir
France, Nantes
Nantes Université
Sdiri-Loulizi, Khira
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Harrath, Rafik
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Fki, Lamia
Tunisia, Sfax
Chu Habib Bourguiba
Hakim, Hèla Karray
Tunisia, Sfax
Chu Habib Bourguiba
Berthomé, Mathilde
France, Nantes
Nantes Université
Billaudel, Sylviane
France, Nantes
Nantes Université
Férré, Virginie
France, Nantes
Nantes Université
Aouni, Mahjoub
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 10
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1007/s11262-007-0093-0
ISSN:
09208569
e-ISSN:
1572994X
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Tunisia