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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy
BMC Medical Genetics, Volume 10, Article 65, Year 2009
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Description
Background: The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers. Methods: We assessed the TIRAP S180L variant by melting curve and RFLP analysis in 1095 delivering women from malaria-endemic Ghana, as well as in a further 1114 individuals participating in case control studies on sepsis and leprosy in Germany, Turkey and Bangladesh. Results: In Ghana, the TIRAP S180L polymorphism was virtually absent. In contrast, the mutation was observed among 26.6%, 32.9% and 12% of German, Bangladesh and Turkish controls, respectively. No significant association of the heterozygous genotype with sepsis or leprosy was observed. Remarkably, homozygous TIRAP 180L tend to increase the risk of sepsis in the German study (P = 0.04). Conclusion: A broad protective effect of TIRAP S180L against infectious diseases per se is not discernible. © 2009 Hamann et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Hamann, Lutz
Unknown Affiliation
Kumpf, Oliver
Unknown Affiliation
Schuring, Ron P.
Unknown Affiliation
Alpsoy, Erkan
Unknown Affiliation
Bedu-Addo, George
Unknown Affiliation
Bienzle, Ulrich
Unknown Affiliation
Oskam, Linda
Unknown Affiliation
Mockenhaupt, Frank Peter
Unknown Affiliation
Schumann, Ralf R.
Unknown Affiliation
Statistics
Citations: 42
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2350-10-65
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Case-Control Study
Study Locations
Ghana
Participants Gender
Female