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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative Stress/Antioxidant, IL-6 and enzyme activities
Biomedical and Environmental Sciences, Volume 22, No. 6, Year 2009
Notification
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Description
To investigate the possible mechanism by which curcumin protects stomach during the acute chronic phase of gastric ulcer disease. Methods The rats were divided into four groups and fasted for 2 days with free access to water. On the third day, the animals were fasted for a further 24 h with no access to water followed by surgery. Rats received different doses of curcumin (20, 40, and 80 mg/kg) or vehicle by oral gavage. Nineteen hours after ulcer induction, the rats were killed by decapitation. Stomach was opened along the greater curvature and ulcerative lesions were counted. Total juice acidity, neutrophils activity, mitochondrial activity, total antioxidants, paraoxonase (PON l)/arylesterase and total peroxides were evaluated. DNA fragmentation (%) and pro-inflammatory cytokine IL-6 level were measured. The level of different gastro-cytoprotective effectors including total antioxidants and paraoxonase (PON l)arylesterase activities was measured. Results The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase (MPO) activity, IL-6 and apoptotic incidence. Conclusion Curcumin appears to have a propitious protective effect against gastric ulcer development. Copyright © 2009 by China CDC.
Authors & Co-Authors
Tuorkey, Muobarak Jaber F.A.
Egypt, Alexandria
Alexandria University
Karolin, K.
Egypt, Alexandria
Faculty of Science
Statistics
Citations: 89
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/S0895-3988(10)60006-2
ISSN:
08953988
Research Areas
Environmental
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study