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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix
International Journal of Surgical Pathology, Volume 15, No. 3, Year 2007
Notification
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Description
The immunoexpression of CK19 recently has been identified as a marker of poor prognosis in pancreatic endocrine tumors and hepatocellular carcinoma. Conversely, the loss of expression of CD99 has been suggested to play a role in the tumorigenesis and dedifferentiation and is associated with poor outcome in some malignancies. The purpose of this study was to explore CK19 and CD99 immunostaining in mucin-producing neuroendocrine (goblet cell) and classical carcinoids of the appendix. Eighteen goblet cell carcinoids (GCCs) and 20 classic carcinoids were stained with CK19, CD99, and Ki-67, and these results were correlated with known pathological features of aggression: extent of invasion, mitoses, necrosis, and histological pattern. All 18 GCCs were CK19 strongly positive, whereas 16/20 classic carcinoids were also CK19 positive. Fourteen of 18 GCCs and 14/20 classic carcinoids were CD99 positive. CK19/CD99 immunoexpression did not correlate with extent of tumor invasion and mesoappendiceal extension, mitotic activity, Ki-67 labeling index, presence of extracellular mucinous pools dissecting muscle, and angiolymphatic and perineural/neural invasion. There is no difference in the immunostaining for CK19 and CD99 between GCCs and classic carcinoids, and both types of neuroendocrine tumor show the same extent of expression of both markers. © 2007 Sage Publications.
Authors & Co-Authors
Alsaad, Khaled Othman
Canada, Toronto
University of Toronto
Serra, Stefano
Canada, Toronto
University of Toronto
Hsieh, Eugene T.K.
Canada, Toronto
Sunnybrook Health Sciences Centre
Chetty, Runjan M.
Canada, Toronto
University of Toronto
Canada, Toronto
University Health Network University of Toronto
Statistics
Citations: 19
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1177/1066896907302118
ISSN:
10668969
Research Areas
Cancer