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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: An observational study in a Ghanaian population
Biomarkers in Medicine, Volume 15, No. 7, Year 2021
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Description
Aim: The study sought to determine the patterns of N-glycan profiles among Type 2 diabetes mellitus (T2DM) patients over a 6-month period. Materials and methods: Biochemical and clinical data were obtained from 253 T2DM patients at baseline and follow-up. Ultra-performance liquid chromatography and statistical methods were applied for N-glycan profiling. Results: The coefficients of variation were 28% and 29% at baseline and follow-up, respectively, whereas the range of N-glycan variability was from 11% to 56%. Apart from GP1 (FA2) and GP29 (FA3G3S [3,3,3]3), the intra-individual variations of N-glycan peaks were not statistically significant. Conclusion: N-glycan profiles were stable over 6-month period in T2DM patients and could be used to monitor biochemical changes in relation with T2DM comorbidities. © 2021 Future Medicine Ltd.
Authors & Co-Authors
Adua, Eric
Unknown Affiliation
Memarian, Elham
Unknown Affiliation
Afrifa-Yamoah, Ebenezer
Unknown Affiliation
Russell, Alyce
Unknown Affiliation
Trbojević-Akmačić, Irena
Unknown Affiliation
Gudelj, Ivan
Unknown Affiliation
Jurić, Julija
Unknown Affiliation
Roberts, Peter
Unknown Affiliation
Lauc, Gordan
Unknown Affiliation
Wang, Wei
Unknown Affiliation
Statistics
Citations: 10
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.2217/bmm-2020-0615
ISSN:
17520363
e-ISSN:
17520371
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study