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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mycobacterium-induced potentiation of type 1 immune responses and protection against malaria are host specific
Infection and Immunity, Volume 73, No. 12, Year 2005
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Description
Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6) and susceptible (BALB/c) mice. C57BL/6 mice coinfected with M. tuberculosis CDC1551 and Plasmodium yoelii 17XL had a lower peak parasitemia and increased survival compared to mice infected with P. yoelii 17XL alone. Splenic microarray analysis demonstrated potentiation of type 1 immune responses in coinfected C57BL/6 mice, which was especially prominent 5 days after infection with P. yoelii 17XL. Splenocytes from coinfected C57BL/6 mice produced higher levels of gamma interferon (IFN-γ) and tumor necrosis factor alpha than splenocytes from mice infected with either pathogen alone. Interestingly, mycobacterium-induced protection against lethal P. yoelii is mouse strain specific. BALB/c mice were significantly more susceptible than C57BL/6 mice to infection with P. yoelii 17XL and were not protected against lethal malaria by coinfection with M. tuberculosis. In addition, M. tuberculosis did not augment IFN-γ responses in BALB/c mice subsequently infected with P. yoelii 17KL. These data indicate that M. tuberculosis-induced potentiation of type 1 immune responses is associated with protection against lethal murine malaria. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Jedlicka, Anne E.
United States, Baltimore
Johns Hopkins University
Noland, Gregory S.
United States, Baltimore
Johns Hopkins University
Kesavan, Anup K.
United States, Baltimore
Johns Hopkins University
Scott, Alan L.
United States, Baltimore
Johns Hopkins University
Kumar, Nirbhay
United States, Baltimore
Johns Hopkins University
Manabe, Yukari C.
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 42
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1128/IAI.73.12.8369-8380.2005
ISSN:
00199567
Research Areas
Cancer
Infectious Diseases