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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Maternal-fetal DNA admixture is associated with intrapartum mother-to-child transmission of HIV-1 in Blantyre, Malawi
Journal of Infectious Diseases, Volume 197, No. 10, Year 2008
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Description
Background. The mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described. Methods. Of 328 HIV-infected mother-infant pairs, we identified 91 that had discordant angiotensin I-converting enzyme and glutathione S-transferase M1 alleles. Maternal alleles in cord blood were quantified with real-time polymerase chain reaction, as indicators of microtransfusions. Results. HIV-1 infected infants had more maternal DNA in cord blood than their uninfected counterparts. Increased maternal DNA in cord blood was associated with preterm delivery, low birth weight, and maternal immunosuppression. Conclusion. Intrapartum MTCT was associated with placental microtransfusions. The associations among placental microtransfusion, in-utero MTCT, maternal immunosuppression, and poor birth outcome should be further investigated. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Kwiek, Jesse J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Columbus
The Ohio State University
Arney, Leslie A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Harawa, Visopo
Malawi, Zomba
University of Malawi
Pedersen, Bonnie R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mwapasa, Victor
Malawi, Zomba
University of Malawi
Rogerson, Stephen J.
Australia, Melbourne
University of Melbourne
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 25
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1086/587646
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Malawi