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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages
Journal of Medical Virology, Volume 81, No. 6, Year 2009
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Description
Although persistent transmission of hepatitis C virus (HCV) from infected mothers to their infants is reported in 4-8%, transient HCV perinatal infection also occurs. This prospective cohort study determined perinatal HCV infection- and early and late clearance-rates in 1,863 mother-infant pairs in rural Egyptian villages. This study found 15.7% and 10.9% of pregnant women had HCV antibodies (anti-HCV) and HCV-RNA, respectively. Among 329 infants born of these mothers, 33 (10.0%) tested positive for both anti-HCV and HCV-RNA 2 months following birth-29 (12.5%) having HCV-RNA positive mothers and 4 (with transient infections) having mothers with only anti-HCV. Fifteen remained HCV-RNA positive at one and/or 2 years (persistent infections), while 18 cleared both virus and antibody by 1 year (transient infections). Among the 15 persistent cases, 7 cleared their infections by 2 or 3 years. At 2- to 6- and at 10- to 12-month maternally acquired anti-HCV was observed in 80% and 5% of infants, respectively. Four perinatally infected and one transiently infected infant were confirmed to be infected by their mothers by the sequence similarity of their viruses. Viremia was 155-fold greater in mothers of infants with persistent than mothers of infants with transient infections. Maternal-infant transmission of HCV is more frequent than generally reported. However, both early and late clearance of infection frequently occurs and only 15 (4.6%) and 8 (2.4%) infants born of HCV-RNA positive mothers had detectable HCV-RNA at one and 2-3 years of age. Investigating how infants clear infection may provide important information about protective immunity to HCV. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Shebl, Fatma Mohamed
United States, Baltimore
University of Maryland School of Medicine
Egypt, Shibin el Kom
Menoufia University
El-Kamary, Samer S.
United States, Baltimore
University of Maryland School of Medicine
Saleh, Doa'a A.
Egypt, Cairo
Faculty of Medicine
Abdel-Hamid, Mohamed A.
United States, Baltimore
University of Maryland School of Medicine
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
NNH Mikhail, Nabiel N.H.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Allam, Alif Abdel Hakim
Egypt, Shibin el Kom
Menoufia University
El-Arabi, Hanaa Ahmed
Egypt, Shibin el Kom
Menoufia University
Elhenawy, Ibrahim A.
Egypt, Shibin el Kom
Menoufia University
A El-Kafrawy, Sherif Aly
Egypt, Shibin el Kom
Menoufia University
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Daly, Maï Mohamed
Egypt, Shibin el Kom
Menoufia University
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Selim, Sahar M.
Egypt, Shibin el Kom
Menoufia University
El-Wahab, Ayman Abd
Egypt, Shibin el Kom
Menoufia University
Mostafa, Mohamed
Egypt, Shibin el Kom
Menoufia University
Sharaf, Soraya A.
Egypt, Shibin el Kom
Menoufia University
Hashem, Mohamed S.
United States, Baltimore
University of Maryland School of Medicine
Heyward, Scott A.
United States, Baltimore
University of Maryland School of Medicine
Stine, Oscar Colin
United States, Baltimore
University of Maryland School of Medicine
Magder, Laurence S.
United States, Baltimore
University of Maryland School of Medicine
Stoszek, Sonia Karolina
United States, Baltimore
University of Maryland School of Medicine
Strickland, George Thomas
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 160
Authors: 20
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.21480
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female