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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic variation in the HLA region is associated with susceptibility to herpes zoster
Genes and Immunity, Volume 16, No. 1, Year 2015
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Description
Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as shingles. Although reactivation may be related to immune suppression, aging and female sex, most inter-individual variability in re-emergence risk has not been explained to date. We performed a genome-wide association analyses in 22 981 participants (2280 shingles cases) from the electronic Medical Records and Genomics Network. Using Cox survival and logistic regression, we identified a genomic region in the combined and European ancestry groups that has an age of onset effect reaching genome-wide significance (P>1.0 × 10-8). This region tags the non-coding gene HCP5 (HLA Complex P5) in the major histocompatibility complex. This gene is an endogenous retrovirus and likely influences viral activity through regulatory functions. Variants in this genetic region are known to be associated with delay in development of AIDS in people infected by HIV. Our study provides further suggestion that this region may have a critical role in viral suppression and could potentially harbor a clinically actionable variant for the shingles vaccine. © 2015 Macmillan Publishers Limited.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4308645/bin/gene201451x1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4308645/bin/gene201451x2.xls
Authors & Co-Authors
Crosslin, David R.
United States, Seattle
University of Washington
Carrell, David S.
United States, Seattle
Group Health Research Institute
Burt, Amber A.
United States, Seattle
University of Washington
Kim, Daniel Seung
United States, Seattle
University of Washington
Comstock, Bryan A.
United States, Seattle
University of Washington
de Andrade, Mariza A.
United States, Rochester
Mayo Clinic
Kullo, Iftikhar J.
United States, Rochester
Mayo Clinic
Tromp, Gerard C.
United States
Geisinger Health System
Kuivaniemi, Helena
United States
Geisinger Health System
Borthwick, Kenneth M.
United States
Geisinger Health System
McCarty, Catherine A.
United States, Duluth
Essentia Institute of Rural Health
United States, Marshfield
Marshfield Clinic
Peissig, Peggy L.
United States, Marshfield
Marshfield Clinic
Doheny, Kimberly Floy
United States, Baltimore
Johns Hopkins University
Pugh, Elizabeth W.
United States, Baltimore
Johns Hopkins University
Kho, Abel Ngo
United States, Evanston
Northwestern University
Pacheco, Jennifer A.
United States, Evanston
Northwestern University
Hayes, Matthew Geoffrey
United States, Evanston
Northwestern University
Ritchie, Marylyn D.
United States, University Park
Pennsylvania State University
Verma, Shefali Setia
United States, University Park
Pennsylvania State University
Denny, Joshua C.
United States, Nashville
Vanderbilt University
Carroll, Robert J.
United States, Nashville
Vanderbilt University
Crawford, Dana C.
United States, Nashville
Vanderbilt University
Crane, Paul K.
United States, Seattle
University of Washington
Mukherjee, Shubhabrata
United States, Seattle
University of Washington
Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Li, Rongling
United States, Bethesda
National Institutes of Health Nih
Keating, Brendan J.
United States, Philadelphia
The Children's Hospital of Philadelphia
Carlson, Christopher S.
United States, Seattle
Fred Hutchinson Cancer Center
Harley, John Barker
United States, Boston
Boston Children's Hospital
Larson, Eric B.
United States, Seattle
Group Health Research Institute
Jarvik, Gail Pairitz
United States, Seattle
University of Washington
Statistics
Citations: 47
Authors: 31
Affiliations: 16
Identifiers
Doi:
10.1038/gene.2014.51
ISSN:
14664879
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Participants Gender
Female