Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The human β-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
European Journal of Immunology, Volume 35, No. 5, Year 2005
Notification
URL copied to clipboard!
Description
We identified the C-type-lectin-like receptor, Dectin-1, as the major receptor for fungal β-glucans on murine macrophages and have demonstrated that it plays a significant role in the cellular response to these carbohydrates. Using two novel, isoform-specific mAb, we show here that human Dectin-1, the β-glucan receptor (βGR), is widely expressed and present on all monocyte populations as well as macrophages, DC, neutrophils and eosinophils. This receptor is also expressed on B cells and a subpopulation of T cells, demonstrating that human Dectin-1 is not myeloid restricted. Both major functional βGR isoforms - βGR-A and βGR-B - were expressed by these cell populations in peripheral blood; however, only βGR-B was significantly expressed on mature monocyte-derived macrophages and immature DC, suggesting cell-specific control of isoform expression. Inflammatory cells, recruited in vivo using a new skin-window technique, demonstrated that Dectin-1 expression was not significantly modulated on macrophages during inflammation, but is decreased on recruited granulocytes. Despite previous reports detailing the involvement of other β-glucan receptors on mature human macrophages, we have demonstrated that Dectin-1 acted as the major β-glucan receptor on these cells and contributed to the inflammatory response to these carbohydrates. © WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Willment, Janet Anne
United Kingdom, Oxford
Sir William Dunn School of Pathology
South Africa, Cape Town
University of Cape Town
Marshall, Andrew S.J.
United Kingdom, Oxford
Sir William Dunn School of Pathology
Reid, Delyth M.
United Kingdom, Compton
Edward Jenner Institute for Vaccine Research
Williams, David L.
United States, Johnson
Quillen-dishner College of Medicine
Wong, Simon Y.C.
United Kingdom, Compton
Edward Jenner Institute for Vaccine Research
Gordon, Siamon
United Kingdom, Oxford
Sir William Dunn School of Pathology
Brown, Gordon D.A.
United Kingdom, Oxford
Sir William Dunn School of Pathology
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 249
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1002/eji.200425725